-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of Ga- and AlF-Labeled Radiopharmaceuticals.

Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important.

Impact of metallic coating on the retention of Ac and its daugthers within core-shell nanocarriers.

Currently, alpha-emitting radionuclide Ac is one of the most promising isotopes in alpha therapy due to its high linear energy transfer during four sequential alpha decays. However, the main obstacle preventing the full introduction of Ac into clinical practice is the lack of stable retention of radionuclides, leading to free circulation of toxic isotopes in the body. In this work, the surface of silica nanoparticles (SiO NPs) has been modified with metallic shells composed of titanium dioxide (TiO) and gold (Au) nanostructures to improve the retention of Ac and its decay products within the developed nanocarriers.

Calcium Carbonate Core-Shell Particles for Incorporation of Ac and Their Application in Local α-Radionuclide Therapy.

Actinium-225 (Ac) radiolabeled submicrometric core-shell particles (SPs) made of calcium carbonate (CaCO) coated with biocompatible polymers [tannic acid-human serum albumin (TA/HSA)] have been developed to improve the efficiency of local α-radionuclide therapy in melanoma models (B16-F10 tumor-bearing mice). The developed Ac-SPs possess radiochemical stability and demonstrate effective retention of Ac and its daughter isotopes. The SPs have been additionally labeled with zirconium-89 (Zr) to perform the biodistribution studies using positron emission tomography-computerized tomography (PET/CT) imaging for 14 days after intratumoral injection.