Application of active biomonitoring technique for the assessment of air pollution by potentially toxic elements in urban areas in the Kemerovo Region, Russia.

In Kemerovo Region (Kuzbass, Southwest Siberia), there is the largest coal basin in Russia and one of the largest in the world. Active moss biomonitoring was applied to assess the impact of potentially toxic elements on air pollution in five urban areas of the region. In each of the chosen urban regions, the moss bags were exposed in November and December of 2022 at locations with varying degrees of anthropogenic pressure.

[Analysis of the effectiveness of cataract surgery in neovascular age-related macular degeneration].

Purpose: This study evaluated the impact of phacoemulsification cataract surgery (PE) on anatomical and functional parameters, as well as the regimen and frequency of anti-VEGF injections in patients with neovascular age-related macular degeneration (nAMD) over a long-term period (up to 3 years).

Material And Methods: The study included 117 patients (117 eyes) diagnosed with nAMD and cataract, graded by LOCS: LOCS I (=56; 47.9%), LOCS II (=57; 48.

Quantification of cancer biomarkers in urine using volatilomic approach.

Urine analysis is an attractive approach for non-invasive cancer diagnostics. In this study, a procedure for the determination of volatile organic compounds (VOCs) in human urine (acetone, acetonitrile, dimethylsulfide, dimethyl disulfide, dimethyl trisulfide, hexane, benzene, toluene, 2-butanone, 2-pentanone, pentanal) has been described including sample preparation using preconcentration of analytes in sorbent tubes followed by gas chromatography with mass spectrometry (GC-MS). Fractional factorial design and constrained surfaces design were used to optimize preconcentration of VOCs in sorbent tubes.

A neutral diphosphene radical: synthesis, electronic structure and white phosphorus activation.

(Im)P-P(Dipp)˙ (1˙), a rare example of a neutral, mixed substituted diphosphene radical, has been prepared by reduction of (Im)PP(Dipp)[OTf] (2[OTf]) and (Im)PP(Cl)(Dipp) (3) with cobaltocene (CoCp) (Im = 4,5-dichloro-1,3-bis(1,3-diisopropylphenyl)-imidazol-2-yl, Dipp = 2,6-diisopropylphenyl). Radical compound 1˙ readily activates white phosphorus (P), resulting in the formation of an intriguing octaphosphane butterfly compound P(Im)(Dipp) (4).

Optogenetic stimulation of medial septal glutamatergic neurons modulates theta-gamma coupling in the hippocampus.

Hippocampal cross-frequency theta-gamma coupling (TGC) is a basic mechanism for information processing, retrieval, and consolidation of long-term and working memory. While the role of entorhinal afferents in the modulation of hippocampal TGC is widely accepted, the influence of other main input to the hippocampus, from the medial septal area (MSA, the pacemaker of the hippocampal theta rhythm) is poorly understood. Optogenetics allows us to explore how different neuronal populations of septohippocampal circuits control neuronal oscillations in vivo.

Negatively Curved Octagon-Incorporated Aza-nanographene and its Assembly with Fullerenes.

A negatively curved aza-nanographene (NG) containing two octagons was synthesized by a regioselective and stepwise cyclodehydrogenation procedure, in which a double aza[7]helicene was simultaneously formed as an intermediate. Their saddle-shaped structures with negative curvature were unambiguously confirmed by X-ray crystallography, thereby enabling the exploration of the structure-property relationship by photophysical, electrochemical and conformational studies. Moreover, the assembly of the octagon-embedded aza-NG with fullerenes was probed by fluorescence spectral titration, with record-high binding constants (K=9.

Tosylazide as N1-Synthon: Iron-Catalyzed Nitrogenative Dimerization of Indoles to -Bisindolopyrazine Derivatives.

We present a straightforward one-step process to access a range of novel -diindolepyrazines via an unprecedented [-BuN][Fe(CO)(NO)] (TBA[Fe])-catalyzed intermolecular nitrogenative dimerization of various indole derivatives. Remarkably, tosylazide functions as a N1-synthon forming the central pyrazine unit that joins the two indole subunits. The catalytic transformation shows a good substrate scope, and the obtained products show interesting electronic properties.

[Prognosis criteria of optical coherence tomography angiography for the long-term efficacy of anti-VEGF therapy of neovascular age-related macular degeneration].

Purpose: The study aimed to determine the most significant optical coherence tomography angiography (OCTA) parameters in terms of predicting anti-VEGF therapy effectiveness during long-term (3-year) follow-up of patients with neovascular age-related macular degeneration (nAMD).

Material And Methods: The study included 122 patients (122 eyes) with mean age of 73.4±6.

[Structure and dynamics of depressive disorders in patients with a new coronavirus infection].

Objective: To analyze the dynamics of depressive disorders in patients who underwent COVID-19.

Material And Methods: The study included female patients (=30) with mean age 35.4±3.

[Three-year follow-up study of clinical effectiveness of antiangiogenic therapy for neovascular age-related macular degeneration].

Purpose: The study analyzes long-term (three years) clinical effectiveness of anti-VEGF treatment of neovascular age-related macular degeneration (nAMD) and attempts to identify the most clinically significant associations between the functional and structural parameters.

Material And Methods: The study included 122 patients (122 eyes) diagnosed with nAMD, mean age -73.4±6.

Differential Expression of Proteins Associated with Bipolar Disorder as Identified Using the PeptideShaker Software.

The prevalence of bipolar disorder (BD) in modern society is growing rapidly, but due to the lack of paraclinical criteria, its differential diagnosis with other mental disorders is somewhat challenging. In this regard, the relevance of proteomic studies is increasing due to the development of methods for processing large data arrays; this contributes to the discovery of protein patterns of pathological processes and the creation of new methods of diagnosis and treatment. It seems promising to search for proteins involved in the pathogenesis of BD in an easily accessible material-blood serum.

Correction to "Non-invasive Exhaled Breath and Skin Analysis to Diagnose Lung Cancer: Study of Age Effect on Diagnostic Accuracy".

[This corrects the article DOI: 10.1021/acsomega.2c06132.

Selectivity of Exhaled Breath Biomarkers of Lung Cancer in Relation to Cancer of Other Localizations.

Lung cancer is a leading cause of death worldwide, mostly due to diagnostics in the advanced stage. Therefore, the development of a quick, simple, and non-invasive diagnostic tool to identify cancer is essential. However, the creation of a reliable diagnostic tool is possible only in case of selectivity to other diseases, particularly, cancer of other localizations.

Functionalization of Carbon Nanotubes Surface by Aryl Groups: A Review.

The review is devoted to the methods of introducing aryl functional groups to the CNT surface. Arylated nanotubes are characterized by extended solubility, and are widely used in photoelectronics, semiconductor technology, and bioelectrocatalysis. The main emphasis is on arylation methods according to the radical mechanism, such as the Gomberg-Bachmann and Billups reactions, and the decomposition of peroxides.

Ibrutinib in combination with rituximab is highly effective in treatment of chronic lymphocytic leukemia patients with steroid refractory and relapsed autoimmune cytopenias.

Autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) are common complications of CLL. The optimal treatment of steroid refractory AIHA/PRCA is not well established. We conducted a multicenter study of ibrutinib and rituximab in patients with relapsed/refractory to steroids AIHA/PRCA and underlying CLL.

[Analysis of the quality of preventive examinations of children (according to the survey of dentists)].

Objective: To improve the methodology for conducting preventive examinations of children by a dentist by identifying and preventing the risks of achieving their qualitative results.

Material And Methods: A test version of the questionnaire was created, which was tested in a pilot study to assess validity and correction. A survey of 100 general dentists in Smolensk, Kaluga, Kaliningrad, Tula, who had previously participated in preventive dental examinations of children, was conducted.

Two-Step Synthesis of B N -Doped Polycyclic Aromatic Hydrocarbon Containing Pentagonal and Heptagonal Rings with Long-Lived Delayed Fluorescence.

Pentagon-heptagon embedded polycyclic aromatic hydrocarbons (PAHs) have aroused increasing attention in recent years due to their unique physicochemical properties. Here, for the first time, this report demonstrates a facile method for the synthesis of a novel B N -doped PAH (BN-2) containing two pairs of pentagonal and heptagonal rings in only two steps. In the solid state of BN-2, two different conformations, including saddle-shaped and up-down geometries, are observed.

Significant reduction in the incidence of non-coronavirus infections in patients with chronic lymphocytic leukemia on ibrutinib and venetoclax treatment during the COVID-19 pandemic: An additional benefit of lockdown.

Effective treatment and prevention of infections challenge management of patients with chronic lymphicytic leukemia (CLL). The COVID-19 pandemic resulted in the reduction of outpatient hospital visits as a part of non-pharmaceutical interventions that could affect the incidence of infectious complications. Study enrolled patients with CLL receiving ibrutinib or/and venetoclax who were observed at the Moscow City Centre of Hematology from 01 April 2017 to 31 March 2021.

Phthalylglycyl Chloride as a Derivatization Agent for UHPLC-MS/MS Determination of Adrenaline, Dopamine and Octopamine in Urine.

Dopamine, adrenaline and octopamine are small polar molecules that play a vital role in regulatory systems. In this paper, phthalylglycyl chloride was proposed as a derivatization agent for octopamine, adrenaline and dopamine determination in urine for the first time. The derivatization procedure facilitated the use of reversed-phase liquid chromatography with positive electrospray ionization-high-resolution mass spectrometry.

Helminth Communities of Common Fish Species in the Coastal Zone off Crimea: Species Composition, Diversity, and Structure.

In this paper, we analyzed the diversity and structure of helminth communities of 12 common fish species from the coastal zone of Crimea. A total of 53 helminth species were found. The total number of parasite species per host fish ranged from 3 to 18.

Non-Invasive Lung Cancer Diagnostics through Metabolites in Exhaled Breath: Influence of the Disease Variability and Comorbidities.

Non-invasive, simple, and fast tests for lung cancer diagnostics are one of the urgent needs for clinical practice. The work describes the results of exhaled breath analysis of 112 lung cancer patients and 120 healthy individuals using gas chromatography-mass spectrometry (GC-MS). Volatile organic compound (VOC) peak areas and their ratios were considered for data analysis.

Eco-Friendly OSN Membranes Based on Alginate Salts with Variable Nanofiltration Properties.

In this work, membranes for organic solvents nanofiltration (OSN) based on a natural polymer, sodium alginate, were fabricated. They are chemically stable in organic solvents, including aprotic polar solvents. The unique advantage of these membranes is the absence of toxic reagents and solvents during their production.