Synopsis of recent research by authors named "Dmitri Pissarnitski"
- Dmitri Pissarnitski’s recent research focuses primarily on the discovery and development of insulin receptor partial agonists (IRPAs) and γ-secretase modulators, aiming to enhance metabolic control in diabetes and Alzheimer’s disease treatment.
- His work includes the identification of novel IRPAs that reduce the risk of hypoglycemia associated with insulin therapy, showcasing their functionally selective signaling properties and broad metabolic benefits.
- Additionally, Pissarnitski has explored the structure-activity relationships (SAR) of various γ-secretase inhibitors, emphasizing the need for compounds that maintain efficacy in reducing amyloid-β levels while minimizing unwanted side effects, particularly concerning Notch signaling modulation.
