Photodynamic therapy with intratumoral administration of Lipid-Based mTHPC in a model of breast cancer recurrence.

Background And Objectives: Generalized skin sensitization is a main drawback of photodynamic therapy with systemic administration of photosensitizers. We have evaluated the potential use of an intratumoral injection of a liposomal formulation of mTHPC (Foslip) in a mouse model of local recurrence of breast cancer.

Materials And Methods: Mice were directly injected into the tumor (IT) with 25 microl of a Foslip suspension (0.