[Metabolic memory enhances hormesis effect to the copper ions in age-depended manner].

The ability of young and old rats to manifest the hormesis effect to lethal doses of copper sulphate and the ability to save the induced "adaptive" pattern of redistribution of copper ions after the transfer of animals in the standard conditions is the mechanism of metabolic memory. It was found that pretreatment of animals with low-dose (1 mg per 100 g body mass, i.e.

[Imprinting effect on the pattern of intracellular distribution of copper ions in the liver following repeated administration of copper sulfate].

Fractions of copper-binding protein (CBP) specifically bound copper ions were extracted from the rat liver cell cytosole. These fractions of 10-14 kDa proteins are involved in specific pattern of intracellular distribution of copper ions. The imprinting effect of specific pattern of copper ions intracellular distribution has been found.

[Supposed role of "metabolic memory" in formation of response reaction to stress-factors in young and adult organisms].

The influence of the combined long-lasted influences of sulfur sulfate and diet restriction in young (3 month age) and adult (21 month age) Vistar rats on activity of glucose-6-phospatase, alaninaminotranspherase (ALT), aspartataminotranspherase (AST), and on phosphorilating activity of liver mitochondria was studied to investigate the role of metabolic memory on the peculiarities of response reaction. The young animals not differed from adult ones in the possibility of inducing activity of glucose-6-phospatase, ALT, and on phosphorilating activity after the influence of sulfur sulfate and diet restriction. The age-related differences in glucose-6-phospatase and transpherases and phosphorilating activity existing in control disappeared after the long-lasted action of sulfur sulfate and diet restriction.

[The growth constraining diet causes various strategy of adaptation in young and adult animals].

The glucose-6-phosphatase activity of microsomes and phosphorylative mitochondrial activity of liver cells, alanine- and aspartate aminotransferase activities in plasma of blood of young (3 month) and adult (21 month) male rats kept under three various diets resulting in a various degree of a growth inhibition and losses of weight of a body have been studied. There were selected diets giving to animals the food full-valued by composition but limited by quantity. Experiment proceeded 50 days.

[Accumulation of lipids in hepatocyte cytosol after local hyperthermia and partial hepatectomy].

The effects of local hyperthermia and partial hepatectomy of the liver as well as of copper ions on the lipid content in liver cell cytosol and microsomes and in blood serum have been studied. It has been found that these effects provoke significant changes in the lipid content of the cytosol and, particularly, of triacylglycerides. Within one hour after partial hepatectomy the lipid content in the liver cytosol increases 2-fold, while by the moment of completion of the regenerative process (day 8th) it decreases sharply--down to 18.

[The effect of exogenous lipids on the functional activity of the liver in experimental hepatitis].

Content of lipids in blood serum and membranes of liver tissue endoplasmic reticulum, functional activity of microsomes, antitoxic activity of liver tissue as well as collagen production in rat liver tissue were studied in experimental hepatitis after administration of exogenous lipids (equine erythrocyte phospholipids and ganglioside GM3, bovine spinal cord phospholipids). All the preparations studied inhibited the functional activity of the liver cells which was expressed as a decrease of the lipids content in the microsomes, inhibition of glucose-6-phosphate dehydrogenase activity and impairment of the liver tissue antitoxic functions. Distinct inhibition of these reactions caused an increase of the collagen content in the liver tissue.

[Lipid metabolism and structure-activity features of the endoplasmic reticulum membrane in regenerating rat liver].

The relationship between the neutral lipid and phospholipid metabolism and some structure-function peculiarities of regenerating rat liver endoplasmic reticulum membranes (13 hours after surgery, i.e., corresponding to the G1-period of the cell cycle) was studied.

[The genetic differences in the microsomal activity of rats].

The lipid composition and synthesis rate in liver microsomes of linear and hybrid rats are investigated. It is found that microsomes of hybrid rats had less amount and synthesis rate of phosphatidylcholine and phosphatidylethanolamine as well as nonesterified fatty acids. Linear rats differed from each other in phosphatidylinositol exchange rate.