Publications by authors named "Dk Jain"

Background: Carcinoma prostate (CaP) is second most common cancer and sixth leading cause of cancer-related mortality among men worldwide. Prostate-specific antigen (sr. PSA) levels are prostate specific, not cancer specific.

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Hepatic edema is caused by decreased hepatic protein synthesis, a consequence of decompensated liver cirrhosis. Fluid accumulation occurs when there is an increase in hydrostatic pressure in the hepatic sinusoids and splanchnic capillaries, as well as low albumin. The first-line treatment for cirrhosis-related ascites is an aldosterone antagonist (spironolactone); however, in severe and recurring ascites, a combination of aldosterone antagonists and loop diuretics (torsemide, furosemide, and bumetanide) is preferable.

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Colonoscopy has attached great importance to early screening and clinical diagnosis of colon cancer. It remains a challenging task to achieve fine segmentation of polyps. However, existing State-of-the-art models still have limited segmentation ability due to the lack of clear and highly similar boundaries between normal tissue and polyps.

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Article Synopsis
  • Omalizumab, an anti-IgE monoclonal antibody, is used to treat conditions like asthma and chronic urticaria and is available in new injection formats for better patient convenience.
  • A study aimed to determine if new injection configurations (PFS-AI and PFS-NSD) were pharmacokinetically bioequivalent to the current configuration, using measurements like concentration (C) and area under the curve (AUC).
  • Results showed that both new configurations met the bioequivalence criteria with confidence intervals within the acceptable range, and safety profiles were consistent with existing data on omalizumab.
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Background: Maxillofacial trauma in polytrauma settings is often associated with multiple injuries both trivial and life threatening, and their timely detection is the mainstay of definitive trauma management for preventing mortality and morbidity. Emergency management of all the patients reporting to our maxillofacial unit is either done by our center or they have been managed at the peripheral health care facility and relatively stable patient is referred to us. Anecdotally, we found inadequacies in transport methods, diagnosis, and detection of associated injuries in the patients referred to us from the peripheral health care facility.

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Background: Solitary fibrous tumors (SFTs) are very rare spindle cell neoplasms of mesenchymal origin with largely benign course of disease. Genital SFT's can be managed providing excellent functional and psychological outcomes by timely intervention.

Case Presentation: We report the largest and possibly the second only reported case of penile SFT in a 34 year male presenting with a gradually increasing perineal mass with clinically normal appearing phallus.

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Purpose: Modified and superficial inguinal lymph node dissection (MILD and SILD) are the 2 widely used templates for surgical staging of clinically node negative (cN0) penile cancer (PeCa); however, no previous reports have compared their outcomes. We compared these 2 surgical templates for oncological outcomes and complications.

Materials And Methods: We retrospectively reviewed records of cN0 PeCa patients who underwent MILD/SILD at our cancer care center from January 2013 to December 2019.

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Central Asian Economies (CAEs) have diverse exchange rate policies. They have recorded higher volatility in the foreign exchange market since inception. High volatility of the transition era has drifted these economies towards partial dollarization.

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Background: Coronavirus disease 2019 (COVID-19) infection in India demonstrated three peaks in India, with differences in presentation and outcome in all the three waves. The aim of the paper was to assess differences in the epidemiological, clinical features and outcomes of patients with COVID-19 presenting at a tertiary care hospital in the three waves at Jaipur, India.

Methods: This was a retrospective study conducted at a tertiary care hospital at Jaipur, India.

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Context: COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emerging pandemic that is rapidly spreading with more than 114 million confirmed cases and 2.5 million deaths by far. Nasopharyngeal swab (NPS) in VTM has been used as the gold standard respiratory specimen for SARS-CoV-2 reverse-transcriptase real-time PCR (rRT-PCR) tests.

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Edentulism, a common problem can occur either as a congenital defect or acquired later due to dental caries, periodontitis, as a consequence of aging, maxillofacial trauma or post-ablation in tumor resections. The rehabilitation of the missing teeth can be done using dental implants. To overcome the deficiency of available bone, processes like sinus augmentation with substituted bone graft and Le Fort I osteotomy with interpositional bone graft have been described in the literature.

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Traditional healthcare services have changed into modern ones in which doctors can diagnose patients from a distance. All stakeholders, including patients, ward boy, life insurance agents, physicians, and others, have easy access to patients' medical records due to cloud computing. The cloud's services are very cost-effective and scalable, and provide various mobile access options for a patient's electronic health records (EHRs).

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The COVID-19 pandemic has caused a worldwide catastrophe and widespread devastation that reeled almost all countries. The pandemic has mounted pressure on the existing healthcare system and caused panic and desperation. The gold testing standard for COVID-19 detection, reverse transcription-polymerase chain reaction (RT-PCR), has shown its limitations with 70% accuracy, contributing to the incorrect diagnosis that exaggerated the complexities and increased the fatalities.

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Introduction: Ewing's sarcoma is a Primary Neuroectodermal Tumour (PNET) commonly affecting appendicular skeleton. The involvement of axial skeleton is very rare and that too of cervical spine is rarest. We present a case of Ewing's sarcoma involving cervical spine managed surgically, and its outcome.

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In lung cancer, tumor histology is a significant predictor of treatment response and prognosis. Although tissue samples for pathologist view are the most pertinent approach for histology classification, current advances in DL for medical image analysis point to the importance of radiologic data in further characterization of disease characteristics as well as risk stratification. Cancer is a complex global health problem that has seen an increase in death rates in recent years.

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For the Pacific Small Island Developing States (PSIDS), climate change will greatly exacerbate their vulnerability. The PSIDS have a high ranking in the Climate Risk Index and the World Risk Index. Financial losses due to climate-induced disasters, in terms of gross domestic product (GDP), are also high in the Pacific region.

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The previous studies of exports performance in Fiji were carried out at the aggregate level. We conduct a disaggregated analysis of exports of three major products, namely, sugar, tourism, and gold. This analysis is useful for developing sector-based export promotion policies.

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The unrelenting trend of doctored narratives, content spamming, fake news and rumour dissemination on social media can lead to grave consequences that range from online intimidating and trolling to lynching and riots in real- life. It has therefore become vital to use computational techniques that can detect rumours, do fact-checking and inhibit its amplification. In this paper, we put forward a model for rumour detection in streaming data on social platforms.

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Over the last decade, the field of bioinformatics has been increasing rapidly. Robust bioinformatics tools are going to play a vital role in future progress. Scientists working in the field of bioinformatics conduct a large number of researches to extract knowledge from the biological data available.

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The paper projects aggregate populations of six Pacific Island countries in both pre- and post-COVID19 scenarios using a Cohort Component Method for the period 2020-2060. It uses baseline indicators resembling China and Italy's experiences and finds that Pacific countries could experience a fatality rate between 5 and 20% due to the pandemic. It also finds that most Pacific Island countries would experience higher fatalities in the older age groups, consistent with what is being witnessed in other countries around the world.

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Background: Ulnar-sided wrist pain is a common clinical problem, most often misdiagnosed as triangular fibrocartilage complex (TFCC) injury. It may be frustrating to the patient, as one may end up wearing a wrist splint for an unusually long period, disrupting their routine.

Purpose: Because of the dilemmas in the diagnosing the cause of ulnar-sided wrist pain, various algorithms have been suggested but it is an individual's choice to do a systematic assessment and follow in their routine clinical practice.

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A major challenge associated with the oral delivery of anti-hypertensive drugs is their poor water solubility and low oral bioavailability. Carvedilol (CAR), a potential beta-blocker is hydrophobic drug that exhibit limited therapeutic effect through oral conventional drug delivery systems. For this reason, it is prerequisite to further investigate and develop an alternative drug delivery system so as to improve therapeutic efficacy of carvedilol as well as to minimize side effects of conventional treatment therapy.

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