Publications by authors named "Djiby Sow"

Background: Niger's National Malaria Control Programme and its partners use histidine-rich protein 2-based RDTs, which are specific to diagnosis. This study aimed to screen for the circulation of non- species in Zinder, a region of Niger, West Africa.

Methods: A cross-sectional study was carried out from July to December 2022 at the district hospital of the Zinder region of Niger.

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Background: Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance.

Methods: Data from two decades (2000-2020) of continuous molecular surveillance of P.

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Background: Following WHO guidelines, microscopy is the gold standard for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation. In this context, we assessed the performance of the laboratory by confirming the reliability and the accuracy of results obtained in accordance with the requirements of the ISO 15189 standards.

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Article Synopsis
  • Genetic surveillance of Plasmodium falciparum can help National Malaria Control Programmes estimate parasite transmission using metrics like multi-strain infections and infection complexity, despite uncertainties about their ability to directly predict clinical incidence.
  • In a study involving 3,147 clinical infections across Senegal from 2012-2020, researchers used genetic analysis to correlate genetic metrics with malaria incidence at different clinic sites.
  • Results indicated that genetic metrics reliably predicted incidence when transmission was high (over 10 cases per 1,000 annually), but showed reversed correlations at lower transmission levels, suggesting a limit to the use of genetics in estimating incidence during low transmission periods.
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Genetic surveillance of the parasite shows great promise for helping National Malaria Control Programs (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polygenomic (multiple strain) infections, genetic clones, and the complexity of infection (COI, number of strains per infection) are correlated with transmission intensity. However, despite these correlations, it is unclear whether genetic metrics alone are sufficient to estimate clinical incidence.

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We here analyze data from the first year of an ongoing nationwide program of genetic surveillance of Plasmodium falciparum parasites in Senegal. The analysis is based on 1097 samples collected at health facilities during passive malaria case detection in 2019; it provides a baseline for analyzing parasite genetic metrics as they vary over time and geographic space. The study's goal was to identify genetic metrics that were informative about transmission intensity and other aspects of transmission dynamics, focusing on measures of genetic relatedness between parasites.

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Epidemiological data predicts that sub-Saharan Africa will have the largest increase in type 2 diabetes (T2D) prevalence over the next two decades. Metabolomics studies have identified biomarkers that could improve T2D diagnosis and follow-up. However, no studies have characterized the metabolome of people from sub-Saharan Africa.

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Article Synopsis
  • Drug resistance to malaria is a big problem that makes it hard to control the disease, especially in Senegal.
  • Researchers studied data from 2000 to 2020 to see how changes in medicine policies affected malaria parasites.
  • They found that when certain drugs were removed or introduced, the parasites changed quickly, showing that we need to watch how well preventive treatments work.
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Article Synopsis
  • Scientists are studying how to use parasite genetics to help control malaria in Senegal.
  • They discovered that having multiple different types of parasites in one person can predict local malaria outbreaks.
  • Most related parasites in the country form a big family, which could help identify where malaria is spreading and if certain drugs are becoming less effective against it.
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In 2006, Senegal adopted artemisinin-based combination therapy (ACT) as first-line treatment in the management of uncomplicated malaria. This study aimed to update the status of antimalarial efficacy more than ten years after their first introduction. This was a randomized, three-arm, open-label study to evaluate the efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP) in Senegal.

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Thyroid abscess is a very rare disease due to its anatomical position and the physiology of the gland. It most often occurs in the immunosuppressed population. The diagnosis is easy and is based on ultrasound.

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Introduction: This study aims to determine the clinical and evolutionary profile of skin and soft tissue lesions in diabetics followed up at the dressing room.

Methods: We conducted an observational descriptive and analytical study in the dressing room of the Marc Sankalé Diabetes Center, Dakar from 1 January to 31 December 2017. Our study focused on diabetics who were examined in the dressing room.

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Pyoderma gangrenosum (PG) is a rare non-infectious neutrophilic dermatosis often unknowed. It usually presents with inflammatory skin ulcer, very painful, with rapid evolution. It is commonly found in a context of malignancy, inflammatory bowel disease, rheumatic and/or haematological disease.

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Fasting glucose (FG) and glycated hemoglobin A1c (HbA1c) perform sub-optimally in people of African origin, especially in individuals with sickle-cell trait (SCT). The purpose of this study was to compare the relationships between HbA1c, FG, and fructosamine in individuals from Senegal with and without SCT. HbA1c, FG, and fructosamine were measured in 203 adults from Senegal (100 control: 45 with type 2 diabetes (T2D); 103 SCT: 51 with T2D).

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Objective: The prevalence of type 2 diabetes (T2D) is rapidly increasing in sub-Saharan Africa, where sickle cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of the development of T2D complications.

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Introduction: Hyperthyroidism in children is rare and constitutes a problem because of its psychosomatic impact. This study aimed to present an overview of the state of knowledge on these aspects in children from Dakar.

Methods: We conducted a multicenter, descriptive study over a period of 15 years.

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