[Hypersensitivity to insulin].

Unlabelled: GREAT PROGRESS: The use of purified insulins obtained by genetics has dramatically lowered the frequency of insulin hypersensitivity. This frequency has decreased from 1 to 55% with non purified insulins and to 0.1 to 2% with newly generated insulins.

Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction.

Background: Drug hypersensitivity reactions are common and can be life-threatening. Confirmation of the diagnosis should be rigorous and based on clinical history and a physical examination, possibly followed by skin tests and drug provocation tests.

Objective: To describe the outcome of drug provocation tests in evaluating patients with histories suggesting drug allergy.