Germ cell testicular tumors in clinical stage A and normal values of serum tumor mark-ers post-orchiectomy: the experience in the management of 300 consecutive patients.

Purpose: To report the outcome and survival of patients with clinical stage A (CS-A) testicular seminoma (TS) treated with adjuvant carboplatin (CBDCA), and the value of primary nerve-sparing retroperitoneal lymphadenectomy (RPLA), adjuvant cisplatin and surveillance in the risk-adapted management of CS-A patients with nonseminomatous testicular tumors (NSTT) and normal values of serum tumor markers post-orchiectomy.

Patients And Methods: From August 1985 to June 2003, 300 patients with CS-A germ cell testicular tumors (GCTT) entered a prospective non-randomized study. 163 patients with TS received post-orchiectomy 2 cycles of adjuvant CBDCA (400 mg/m(2) q 3 wks).

An evaluation of high-doses ketoconazole with hydrocortisone substitution in hormone-refractory prostate cancer.

We investigated the efficacy of ketoconazole, an inhibitor of testicular and adrenal biosynthesis, for treating patients with progression of hormone-refractory prostate cancer. The study comprised 35 patients with progressive disease despite salvage treatment with estramustine with or without vinblastine. Treatment consisted high-doses ketoconazole (400 mg three times daily) and hydrocortisone substitution.