Air quality in different urban hotspots in a metropolitan city in India and the environmental implication.

This research study investigates hourly data on concentrations of five major air pollutants such as particulate matter (PM, PM) and gaseous pollutants (SO, NO, CO) measured during 2022 at four hotspot sites (industrial site, traffic site, commercial site, harbour, and one residential site) in Chennai, India. The analysis encompasses temporal variations spanning annual, seasonal, and diurnal variations in the pollutants. Notably, PM and CO emerge as the predominant pollutants, with the highest concentrations at industrial and traffic sites (PM: 67.

RP1 and retinitis pigmentosa: report of novel mutations and insight into mutational mechanism.

Background/aim: Retinitis pigmentosa (RP) is the commonest form of retinal dystrophy and is usually inherited as a monogenic trait but with remarkable genetic heterogeneity. RP1 is one of the earliest identified disease genes in RP with mutations in this gene known to act both recessively and dominantly although the mutational mechanism remains unclear. This study is part of our ongoing effort to characterise RP in Saudi Arabia at the molecular level.