Focal Cortical Dysplasia (FCD) & Mesial Temporal Lobe Epilepsy-Hippocampal Sclerosis (MTLE-HS) are two common pathologies of drug-resistant focal epilepsy (DRE). Inappropriate localization of the epileptogenic zones (EZs) in FCD is a significant contributing factor to the unsatisfactory surgical results observed in FCD cases. Currently, no molecular or cellular indicators are available which can aid in identifying the epileptogenic zones (EZs) in FCD.
View Article and Find Full Text PDFCancer stem cells (CSCs) are responsible for chemoresistance and tumor relapse in many solid malignancies, including lung and ovarian cancer. Ellagic acid (EA), a natural polyphenol, exhibits anticancer effects on various human malignancies. However, its impact and mechanism of action on cancer stem-like cells (CSLCs) are only partially understood.
View Article and Find Full Text PDFJ Phys Condens Matter
December 2024
The industrialization has severely impacted the ecosystem because of intensive use of chemicals and gases, causing the undesired outcomes such as hazardous gases, e.g., carbon monoxide (CO), nitrox oxide (NOx), ammonia (NH3), hydrogen (H2), hydrogen sulfide (H2S) and even volatile organic compounds.
View Article and Find Full Text PDFUnlabelled: Wheat ( L.), a vital cereal crop, provides over 20% of the total calories and protein in the human diet. However, , the pathogen responsible for Fusarium head blight (FHB), poses a significant threat to wheat production by contaminating grains with harmful mycotoxins.
View Article and Find Full Text PDFBackground: To help inform COVID-19 vaccination recommendations, we evaluated the impact of age and dosing interval on clinical benefit of a third dose of mRNA-1273.
Methods: Approximately 17 000 participants from the phase 3 Coronavirus Efficacy trial who previously received 2 doses of 100 µg mRNA-1273 were evaluated for COVID-19 between September 2021 and April 2022 during uptake of a third booster dose of 50 µg of mRNA-1273. Cox models assessed booster relative efficacy of a third dose.
Objective: Vagus nerve stimulation (VNS) paired with rehabilitation therapy improved motor status compared to rehabilitation alone in the phase III VNS-REHAB stroke trial, but treatment response was variable and not associated with any clinical measures acquired at baseline, such as age or side of paresis. We hypothesized that neuroimaging measures would be associated with treatment-related gains, examining performance of regional injury measures versus global brain health measures in parallel with clinical measures.
Methods: Baseline magnetic resonance imaging (MRI) scans in the VNS-REHAB trial were used to derive regional injury measures (extent of injury to corticospinal tract, the primary regional measure; plus extent of injury to precentral gyrus and postcentral gyrus; lesion volume; and lesion topography) and global brain health measures (degree of white matter hyperintensities, the primary global brain measure; plus volumes of cerebrospinal fluid, cortical gray matter, white matter, each thalamus, and total brain).
Using the Culturally Engaging Campus Environments (CECE) Model, this qualitative study examined development of psychosocial attributes (i.e., sense of belonging, science identity, and self-efficacy) among 1st-year life science undergraduate students who participated in integrated and culturally engaging research activities at New Mexico Highlands University, a rural Hispanic Serving Institution (HSI).
View Article and Find Full Text PDFBackground: Social norms shape adolescent sexual and reproductive health behaviours contributing to contraceptive and pregnancy outcomes. No global research agendas exist to guide research on adolescent social norms shifting in low- and middle-income countries (LMICs). We developed a social norms research agenda to improve adolescent healthy timing and spacing of pregnancy in LMICs.
View Article and Find Full Text PDFOlfactory pathway and limbic system demonstrate a close nexus, which paves common ground for investigating the effects of smell on emotions, cognitive load and autonomic functions. Notably, olfactory stimulation during the administration of cognitive load may interfere with the performance. The study is planned to investigate the effect of citrus inhalation on cognitive performance, through psychophysiological assessments.
View Article and Find Full Text PDFObjectives: Although medication abortion drugs technically require a prescription in India, research suggests that they are often available directly from pharmacies. We conducted a mystery client study in the capital city of Delhi to explore the availability, accessibility, and pharmacy dispensing practices of mifepristone/misoprostol in the absence of a prescription.
Study Design: Using two predetermined client profiles-one of an unmarried woman and one of her male partner-we visited community pharmacies in different neighborhoods.
Indian J Psychol Med
September 2024
Superconducting diode effects have recently attracted much attention for their potential applications in superconducting logic circuits. Several pathways have been proposed to give rise to non-reciprocal critical currents in various superconductors and Josephson junctions. In this work, we establish the presence of a large Josephson diode effect in a type-II Dirac semimetal 1T-PtTe facilitated by its helical spin-momentum locking and distinguish it from extrinsic geometric effects.
View Article and Find Full Text PDFEstimation of the glacier-stored freshwater is important to understand the water security in the Himalayan region. While previous work has studied the western and central Himalayan glaciers, the eastern counterpart received less and more scattered attention. In this study, an attempt is made to quantify the total glacier-stored freshwater in the Brahmaputra basin and later compared with previous global models.
View Article and Find Full Text PDFSmall molecule probes exist for only ∼2% of human proteins because most lack functional binding pockets or cannot be assayed for high-throughput screening. Selective translation modulation circumvents canonical druggability and assay development constraints by using in vitro transcription-translation (IVTT) as a universal biochemical screening assay. We developed an IVTT activity assay by fusing a GFP reporter to various target gene sequences and screened the target sequences for inhibitors in microfluidic picoliter-scale droplets using a 5,348-member translation inhibitor DNA-encoded library (DEL).
View Article and Find Full Text PDFDr. Roger Guillemin was a French physiologist who won the Nobel Prize in 1977. His pioneering research and fierce competition led to the isolation and identification of hypothalamic hormones, including thyrotropin-releasing factor (TRF), luteinizing hormone-releasing factor (LRF), and somatostatin.
View Article and Find Full Text PDFCoinfection of pathogenic bacteria and viruses is associated with multiple diseases. During the COVID-19 pandemic, the co-infection of other pathogens with SARS-CoV-2 was one of the important determinants of the severity. Although primarily a respiratory virus gastric manifestation of the SARS-CoV-2 infection was widely reported.
View Article and Find Full Text PDFGandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, (DC.) Rehder & E.
View Article and Find Full Text PDFIntroduction: The aim of the study was to assess and compare the efficacy of autotransplantation of molars with complete and incomplete root formation, by checking the viability of the procedure to replace non-restorable molar teeth in the extraction sockets.
Materials And Methods: Twenty patients with non-restorable molars were included in this study. They were divided into two groups with complete and incomplete root-formed third molars, which needed to be transplanted in place of non-restorable molars.
Background: One potential long-term side effect of surgery in the oral and maxillofacial region is neurosensory impairment. Due to their physical proximity to the surgical location, the lingual nerve (LN) and inferior alveolar nerve (IAN), two sensory segments of the trigeminal nerve, are always susceptible to damage during third molar extraction.
Aim: Assessment of the impact of different surgical techniques on nerve function and sensation after maxillofacial surgery.
Correlation between rugoscopy and lateral cephalometric radiographic technique for gender determination is of interest. A cross sectional study was conducted on 100 subjects within an age group of 20 to 50 years. Distribution of rugae patterns and morphometric analysis of maxillary sinus was done for gender correlation.
View Article and Find Full Text PDFJ Ayurveda Integr Med
September 2024
A 42-year-old male patient presented with complaints of vertigo, neck pain, swallowing difficulties, and difficulty in maintaining an upright posture. The patient took allopathic consultation for the complaints and was advised to undergo MDCT scan of brain, hematological and audiological evaluations. No abnormalities were detected in the investigations and he was given some medications for symptomatic management.
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