Exploring the interaction of Valsartan and Valsartan-Zn(ll) complex with DNA by spectroscopic and in silico methods.

Belonging to the Sartan family, antihypertensive drug - Valsartan (Val) had been found to possess antioxidant properties. Also, the zinc complex of Valsartan (VZn) has been recently recognized as inducing agents of the reductive stress effects thus possessing anticancer activity. Hence, in this work an attempt has been made to understand the interaction of Val and VZn with DNA using spectroscopic and in silico methods as DNA has been identified as the target for many anticancer drugs.

Novel and Reliable Chemosensor Based on C. dots from Sunflower seeds for the Distinct Detection of Picric Acid and Bilirubin.

Based on the green chemistry approach, highly fluorescent and novel carbon dots (C. dots) were synthesized from naturally available and cost effective sunflower seeds. The obtained C.

Effect of quercetin on the amiloride-bovine serum albumin interaction using spectroscopic methods, molecular docking and chemometric approaches.

The effect of quercetin flavonoid (QUE), on the binding interaction of antihypertensive drug, amiloride (AMI) with bovine serum albumin (BSA) was investigated in this study. Spectroscopic methods such as steady-state, synchronous, three-dimensional fluorescence, and circular dichroism spectroscopy were employed to study the interaction. Fluorescence data were analyzed using the Stern-Volmer equation and a static quenching process was found to be involved in the formation of AMI-BSA and QUE-BSA complexes and were in good agreement with the thermodynamic study.

Bioimaging Applications of Carbon dots (C. dots) and its Cystamine Functionalization for the Sensitive Detection of Cr(VI) in Aqueous Samples.

In this study, one step hydrothermal synthetic strategy was adopted for preparing carbon dots (C. dots) from jeera (Cumin: Cuminum cyminum), a naturally abundant and cost effective carbon source. The physical, optical and surface functional properties of C.

Investigation of complexation of amlodipine with lysozyme and its effect on lysozyme crystal growth.

Lysozyme (LYZ) is a model protein frequently employed to study interaction with drugs and to understand the crystallization process of protein due to its small size and rapid crystallization behavior. Studies related to drug interaction and complexation with proteins will be significantly benefited if a suitable drug-lysozyme crystal is available. This can further aid in the understanding of the mechanism of nucleation, growth and the formation of drug-lysozyme complex.

Comprehensive analysis of the atenolol - DNA complex by viscometric, molecular docking and spectroscopic techniques.

This paper discusses multi-spectroscopic and molecular docking analysis of the interaction between atenolol (ATN) and deoxyribose nucleic acid (DNA) using alizarin (ALZ) as a spectroscopic probe. ATN is a β -receptor antagonist belonging to the β-blocker class of molecules. Experimental findings that were based on different spectroscopic analysis, melting studies, viscometric analysis, H nuclear magnetic resonance and circular dichroism studies revealed the presence of a grove-binding mode.

A Selective Turn off Fluorescence Sensor Based on Propranolol-SDS Assemblies for Fe Detection.

A fluorophore modulation with sodium dodecyl sulphate (SDS) assemblies for the selective and sensitive sensing of Fe ions in aqueous solution is illustrated in this work. Emission spectral characteristics of fluorescent molecule, propranolol (PPH) was intact in presence of metal ions. While on modulation with SDS assemblies, PPH was transformed into a tuneable sensor for Fe ions.

Medium dependent dual turn on/turn off fluorescence sensing for Cu ions using AMI/SDS assemblies.

Behavior of Amiloride (AMI) as a metal ion sensor in anionic surfactant assemblies of varying concentrations at different pH is depicted in this work. From a non-sensor fluorophore, AMI has been transformed in to a tunable fluorosensor for Cu ions in various SDS concentrations. At premicellar concentration of SDS, ion-pair complex is expected to be formed between AMI and SDS due to electrostatic interactions between them.

Understanding the electron transfer process in ZnO-naphthol azobenzoic acid composites from photophysical characterisation.

Semiconductor nanoparticles surface modified with organic molecules capable of visible light absorption and effectively transferring the electrons to the catalytic sites have the potential to be good photocatalysts. ZnO nanoparticles of size ∼3 nm are grafted with two azonaphthols, one conjugated and the other non-conjugated. The photophysical properties of modified ZnO indicate an effective electron transfer from the conjugated azonaphthol to ZnO but not in the case of the non-conjugated molecule.