Publications by authors named "Divya Mathew"

Food safety is a global concern due to the risk posed by microbial pathogens, toxins and food deterioration. Hence, materials with antibacterial and antioxidant properties have been widely studied for their packaging application to ensure food safety. The current study has been designed to fabricate the chitosan/starch-based film with cinnamon essential oil (CEO) and cellulose nanofibers for active packaging.

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  • This study compared the clinical severity and outcomes of hospitalized COVID-19 patients in India during the first wave (April-Dec 2020) and the second wave (April-May 2021).
  • Results showed that the second wave had a significantly higher proportion of critical illness, increased need for oxygen and other treatments, and higher mortality rates (19.2% compared to 9.3%).
  • Key factors associated with higher mortality included being over 60, having high D-dimer levels, requiring supplemental oxygen, and being hospitalized during the second wave.
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Purpose: Stenotrophomonas maltophilia is an emerging multi-drug resistant pathogen increasingly isolated in India. This study aimed to identify patients from whom Stenotrophomonas maltophilia had been isolated and assess predictors of mortality in this population.

Methods: This was a retrospective cohort study of hospitalized patients with a positive culture for S.

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We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.

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  • The text discusses an ornamental herb found mainly in South India and Sri Lanka that is highly toxic, particularly its tuberous rhizomes, due to a substance called colchicine.
  • It reports a case of a patient who ingested the tubers with the intent to self-harm, resulting in severe medical complications such as systemic coagulopathy and organ dysfunction.
  • The case highlights the importance of recognizing symptoms associated with plant poisonings and the need for greater awareness among healthcare providers, especially in regions where these plants are easily accessible.
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In this review, the concept and various strategies in molecular imprinting is discussed briefly. How the concept of transition state analogue can be used to design a template to prepare catalytic imprinted polymers is described in detail. The use of the "bait and switch" approach and alternative covalent template strategies show how functional groups which assist in the catalytic properties can be assembled within the imprint.

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The morphology of the polymer network - porous/less porous - plays predominant role in the amidase activities of the polymer catalysts in the hydrolytic reactions of amino acid p-nitroanilides. Polymers with the imprints of stable phosphonate analogue of the intermediate of hydrolytic reactions were synthesized as enzyme mimics. Molecular imprinting was carried out in thermodynamically stable porogen dimethyl sulphoxide and unstable porogen chloroform, to investigate the morphological effects of polymers on catalytic amidolysis.

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Enzyme-like polymer catalysts with the imprints of phosphonate transition state analogue (TSA) lined along with imidazole and pyridine moieties were synthesized using methacryloyl-l-histidine and 4-vinylpyridine as the functional monomers and phenyl-1-(N-benzyloxycarbonylamino)-2-(phenyl)ethyl phosphonate - the TSA of hydrolytic reaction as the template for the amidolysis of N-benzyloxycarbonyl-l-phenylalanine p-nitroanilide (Z-l-Phe-PNA). Polymers containing different functional groups can act together to provide catalytic activity and selectivity superior to what can be obtained from monofunctional analogues. The higher rate acceleration exhibited by the bifunctional polymer over the monofunctional polymers indicates cooperative catalysis of imidazole and pyridine moieties.

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  • 14-3-3 proteins are important molecular chaperones that help regulate various cellular functions, and are linked to neurodegenerative diseases and alcohol use disorders.
  • Five out of seven 14-3-3 transcripts were significantly down-regulated after chronic ethanol treatment in HEK293T cells, mirroring changes observed in the brains of human alcoholics, while one transcript increased in expression.
  • Following miRNA transfection, only miR-203 down-regulated 14-3-3θ, but miR-7 and miR-144 led to upregulation of other isoforms, suggesting miRNA may affect neurotransmission and cellular balance in the context of alcohol exposure.
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