Shark chondroitin sulfate gold nanoparticles: A biocompatible apoptotic agent for osteosarcoma.

Osteosarcoma is a highly aggressive tumor that originates in the bone and often infiltrates nearby bone cells. It is the most prevalent type of primary bone cancer among the various bone malignancies. Traditional cancer treatment methods such as surgery, chemotherapy, immunotherapy, and radiotherapy have had restricted success.

Evaluating the role of quantitative computed tomography perfusion parameters in differentiating hepatocellular carcinoma from other hepatic neoplasms.

Background: Differentiating the various liver tumors is pivotal due to distinct treatments and prognoses. Sometimes, it is difficult to accurately differentiate hepatocellular carcinoma (HCC) from other hepatic neoplasms non-invasively because of overlap in the triple-phase contrast-enhanced computed tomography (CECT) features, contraindication of an invasive biopsy, particularly in multifocal lesions with cirrhosis or ascites or when an MRI is unavailable or not feasible.

Objectives: To assess the utility of CT perfusion (CTP) parameters in differentiating HCC from other hepatic neoplasms.

Efficacy of chondroitin sulfate as an emerging biomaterial for cancer-targeted drug delivery: A short review.

The global increase in cancer incidence over the past decade highlights the urgent need for more effective therapeutic strategies. Conventional cancer treatments face challenges such as drug resistance and off-target toxicity, which affect healthy tissues. Chondroitin sulfate (CHDS), a naturally occurring bioactive macromolecule, has gained attention because of its biocompatibility, biodegradability, and low toxicity, positioning it as an ideal candidate for cancer-targeted drug delivery systems.

Virulence perspective genomic research unlocks the secrets of associated with banded sheath blight in Barnyard Millet ().

Introduction: Banded sheath blight (Bsb) disease, caused by , is an emerging problem in barnyard millet cultivation. One of the significant goals of pathogenomic research is to identify genes responsible for pathogenicity in the fungus.

Methods: A virulence profiling-based approach was employed and six isolates were collected from various ecological zones of India.

A Rare Case of Lymphoproliferative Disorder in Pregnancy: A Case Report.

Lymphoproliferative disorders in pregnancy are rare. Among that, Castleman disease is an uncommon lymphoproliferative disorder in pregnancy with an unknown etiology. Many cases have not been encountered more often in practice and are easily misdiagnosed due to their rarity.

Revolutionizing healthcare: Harnessing nano biotechnology with zinc oxide nanoparticles to combat biofilm and bacterial infections-A short review.

A crucial pathogenic mechanism in many bacterial diseases is the ability to create biofilms. Biofilms are suspected to play a role in over 80 % of microbial illnesses in humans. In light of the critical requirement for efficient management of bacterial infections, researchers have explored alternative techniques for treating bacterial disorders.

Dyslexia: An invisible disability or different ability.

Background: With a global dyslexia prevalence of at least 10%, significant numbers of students with dyslexia go undiagnosed and their symptoms unaddressed, but with timely intervention, 90% of dyslexic children can be educated in regular inclusive classrooms.

Aim: This study aimed to estimate the prevalence of dyslexia among primary schoolchildren in government and private schools.

Material And Methods: A cross-sectional study on 128 primary schoolchildren attending selected government and private schools in Western Maharashtra was conducted and evaluated using the Search tool, which is a standardized study tool for screening dyslexia.

Biomedical and ecosafety assessment of marine fish collagen capped silver nanoparticles.

In the rapidly evolving landscape of silver nanoparticles (Ag NPs) synthesis, the focus has predominantly been on plant-derived sources, leaving the realm of biological or animal origins relatively uncharted. Breaking new ground, our study introduces a pioneering approach: the creation of Ag NPs using marine fish collagen, termed ClAg NPs, and offers a comprehensive exploration of their diverse attributes. To begin, we meticulously characterized ClAg NPs, revealing their spherical morphology, strong crystalline structure, and average diameter of 5 to 100 nm.

Prediction of Maternal Morbidity and Mortality Risk Among Women with Medical Disorders Presenting to Emergency Obstetric care (EMOC): A Prospective Observational Study.

Introduction: Medical disorders complicating pregnancy have recently emerged as the most common cause for maternal morbidity and mortality and it is important to predict mortality risk when they present in moribund state to emergency obstetric care so as to take and timely effective measures to prevent mortality.

Methods: This prospective observational study was conducted over 6 months among pregnant and post-partum women with medical disorders who sought emergency obstetric care at a tertiary care hospital. Severity of morbidity was assessed using SOFA and APACHE II scores at admission.

Transcriptomic approaches for identifying potential transmission blocking vaccine candidates in : a review of current knowledge and future directions.

Unlabelled: Utilizing transcriptomics, promising methods for identifying unique genes associated with gametocyte development offer a potential avenue for novel candidate targets in transmission blocking vaccine development. In this review, we identified 40 publicly available transcriptomic datasets related to parasite factors linked with sexual stage transmission, from which we analyzed two RNA-Seq datasets to identify potential genes crucial for the transmission of from humans to mosquito vectors. Differential expression analysis revealed 3500 (2489 upregulated and 1011 downregulated) common genes differentially expressed throughout sexual stage development of occurring in both humans (gametocyte stage II, V) and mosquitoes (ookinete).

Management and outcomes of pulmonary artery hypertension and Eisenmenger syndrome during pregnancy: a prospective observational cohort study.

Objectives: Maternal-fetal morbidity and mortality among pregnant women with pulmonary artery hypertension (PAH) and Eisenmenger syndrome are unacceptable, and management decision-making in these clinical scenarios remains debatable. This study aimed to compare and analyse clinical characteristics, management and pregnancy outcomes in PAH and Eisenmenger syndrome.

Design: Prospective observational cohort study.

Therapeutics through glycobiology: an approach for targeted elimination of malaria.

The emergence of drug resistance in jeopardises worldwide malaria eradication efforts necessitating novel therapeutic approaches and therefore the identification of key metabolic pathways of parasite and human host for drug development garners importance. Enzymopathies like glucose-6-phosphate-dehydrogenase (G6PD) and pyruvate kinase (PK) deficiencies have been shown to protect against the severe consequences of malaria. Glycome profiles and the regulatory mechanisms involving the microRNAs or transcription factors' expression related to the histo-blood group glycogenes may add up to resolve the underlying pathogenesis.

Disposal Methods of Used Pressurized Metered Dose Inhalers and Spacers by Families of Children With Asthma.

The choice of disposal method of used pressurized metered dose inhalers and spacers by families of children with asthma were evaluated by a questionnaire. The disposal methods used for inhalers and spacers by the 120 children enrolled included giving to plastic/metal waste collectors (28.3% and 33.

Root Bark Extract of Vent. Inhibits Solid and Ascites Tumors and Prevents the Development of DMBA-Induced Skin Papilloma Formation.

is a traditionally used plant in Ayurvedic and folk medicines. The plant is useful for the management of gastrointestinal diseases as well as skin diseases. In the present study, we analyzed the antitumor potential of in Dalton's lymphoma ascites tumor cells (DLA) and Ehrlich ascites carcinoma (EAC)-induced solid and ascites tumors.

High Operation Frequency and Strain Tolerance of Fully Printed Oxide Thin Film Transistors and Circuits on PET Substrates.

The major limitations of solution-processed oxide electronics include high process temperatures and the absence of necessary strain tolerance that would be essential for flexible electronic applications. Here, a combination of low temperature (<100 °C) curable indium oxide nanoparticle ink and a conductive silver nanoink, which are used to fabricate fully-printed narrow-channel thin film transistors (TFTs) on polyethylene terephthalate (PET) substrates, is proposed. The metal ink is printed onto the In O nanoparticulate channel to narrow the effective channel lengths down to the thickness of the In O layer and thereby obtain near-vertical transport across the semiconductor layer.

The Role of Diffusion Tensor Tractography in Assessment of Spondylotic Myelopathy.

Introduction Cervical spondylotic myelopathy (CSM) describes a neurological deficit related to the spinal cord due to the changes in the facet joints and discs of the cervical spine as a result of degeneration. Diagnosis is mainly dependent on imaging. Diffusion tensor tractography (DTT), being a non-invasive technique, shows better sensitivity when compared to the conventional T2WI sequence in the early detection of cervical spondylotic myelopathy (CSM).

Therapeutic Effect of Multi-Channel Transcranial Direct Current Stimulation (M-tDCS) on Recovery of Cognitive Domains, Motor Functions of Paretic Hand and Gait in Subacute Stroke Survivors-A Randomized Controlled Trial Protocol.

Background: There has been rapid drift of rehabilitation professionals toward the clinical use of technology aided electrical interventions. Brain is a cortical hub of functionally related neural connections. Motor learning entails strong interaction with the cognitive domains.

Patients with Neurological Illnesses and Their Experience During the Lockdown: A Teleinterview-based Study.

Background: Governments have imposed lockdowns in the wake of the COVID-19 pandemic. Hospitals have restricted outpatient clinics and elective services meant for non-COVID illnesses. This has led to patients facing unprecedented challenges and uncertainties.

Whole genome sequencing data of native isolates of and having potential biocontrol and plant growth promotion activities in rice.

Six native isolates of and having potential for biocontrol and plant growth-promoting activities in rice were isolated from different rice growing regions of India. These isolates were screened for their efficiency in both and conditions for three years. The identity of the isolates was confirmed both by morphological and molecular characterization.

Impact of polystyrene microplastics on major marine primary (phytoplankton) and secondary producers (copepod).

The effect of microplastic adsorption on marine microalgae Tetraselmis suecica, Amphora subtropica, and copepod Pseudodiaptomus annandalei was investigated in the present study. Fluorescence microscopic images were used to evaluate MP interactions with algae and copepods. T.

Evaluation of phytochemicals, enzyme inhibitory, antibacterial and antioxidant effects of Gaertn.

The study was aimed to investigate the phytochemical composition, antioxidant, antibacterial and enzyme inhibitory effects of leaf (PDL). Hydroalcoholic extract (HAE) was recorded with high concentration of total phenolics (59.68 ± 0.

Amelioration of sodium fluoride induced oxidative stress by Bedd in mice.

Objectives: , endemic to Western Ghats of India is pharmacologically similar to and occasionally used as substitute in a well-known Ayurvedic uterine tonic . possess various biological properties, but there are no reports on The present study evaluated the pharmacological properties of and its efficacy in attenuating the sodium fluoride (NaF) induced oxidative stress in mice.

Methods: Antioxidant potential of methanolic extract of .

Effects of Traditional Indian Dance on Motor Skills and Balance in Children with Down syndrome.

The objective of the study was to examine the effects of traditional Indian dances like Bharatanatyam, Kuchipudi and Kathak on motor skills and balance in children with Down syndrome compared to neuromuscular training. In this randomised double-arm design, 36 children with Down syndrome aged 6-10 years and with a score of <5 in Beighton's hypermobility test participated in either Indian classical dance (n = 18) or neuromuscular training (n = 18). Both the groups practised an hour-long session a day, three days a week for six weeks in six special-schools.