Publications by authors named "Divya Khatter"

Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here, we report that Arl8b binds to the Rab4 and Rab14 interaction partner, RUN and FYVE domain-containing protein (RUFY) 1, a known regulator of cargo sorting from recycling endosomes.

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Article Synopsis
  • Lysosomes are organelles that not only degrade cellular materials but also assist in important functions like cholesterol balance, cell repair, and immune responses.
  • Recently identified, the small GTPase Arl8b plays a critical role in directing lysosome movement within cells by interacting with kinesin motor proteins.
  • This review highlights Arl8b's various functions in lysosomal traffic, including its involvement in immune cell activities and responses to intracellular infections.
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The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential for membrane localization of the human (h)Vps41 subunit of the HOPS complex.

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