Publications by authors named "Divya K"

Treatment of Burkitt Lymphoma/Leukemia (BL/L) in adults has evolved from the use of pediatric inspired regimens (CODOX-M/IVAC, hyper-CVAD, GMALL) to the use of lower intensity EPOCH regimens. The addition of rituximab has led to improvements in overall survival. Survival with these regimens in the real world was shown to be inferior as compared to those found in the prospective trials.

View Article and Find Full Text PDF

The rise of various diseases demands the development of new agents with antioxidant, antimicrobial, anti-inflammatory, enzyme-inhibiting, and cytotoxic properties. In this study, heterocyclic Schiff base complexes of Cu(II) featuring a benzo[]thiophene moiety were synthesized and their biological activities evaluated. The complexes were characterized using FT-IR, UV-Vis, and EPR spectroscopy, TG-DTG analysis, magnetic moment measurements, molar conductivity measurements, and elemental analyses.

View Article and Find Full Text PDF

Introduction: Dermoscopy is an important noninvasive tool that helps to determine the stability and activity of vitiligo. Various dermoscopic findings help classify the disease as stable or unstable. This is important for the management of the disease, as surgical management requires disease stability.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated how COVID-19 disruptions affected neuroscience research projects and young researchers in India through an online survey targeting medical trainees, post-docs, PhD students, and early career faculty.
  • A total of 504 valid responses revealed that over 83% of participants experienced negative impacts on their research, with one-third noting delays and many adapting their methodologies due to the pandemic.
  • The findings highlighted significant challenges, particularly for those involved in prospective studies, emphasizing the need for focused support for neuroscience research in the post-pandemic landscape.
View Article and Find Full Text PDF

Background And Objectives: Next-generation sequencing (NGS) has expedited the diagnostic process and unearthed many rare disorders in leukodystrophy (LD) and genetic leukoencephalopathy (gLE). Despite the progress in genomics, there is a paucity of data on the distribution of genetic white matter disorders (WMDs) and the diagnostic utility of NGS-based assays in a clinical setting. This study was initiated to explore the clinical, radiologic, and genetic spectrum of LD and gLE in the Indian population and also to estimate the diagnostic yield of clinical exome sequencing (CES).

View Article and Find Full Text PDF

Introduction: Menopause is an unspoken and unaddressed aspect of a women's life, surrounded by many myths and taboos within the Indian context. Although a majority of menopausal women experience moderate to severe symptoms that can affect their physical, emotional, mental, and social well-being, there is poor health literacy as well as health-seeking behavior among them. The importance of social support, especially at a difficult time like menopause, is bound to minimize the severity of menopausal symptoms.

View Article and Find Full Text PDF

Cardiovascular diseases (CVDs) can be described as a global health emergency imploring possible prevention strategies. Although the pathogenesis of CVDs has been extensively studied, the role of mitochondrial dysfunction in CVD development has yet to be investigated. Diabetic cardiomyopathy, ischemic-reperfusion injury, and heart failure are some of the CVDs resulting from mitochondrial dysfunction Recent evidence from the research states that any dysfunction of mitochondria has an impact on metabolic alteration, eventually causes the death of a healthy cell and therefore, progressively directing to the predisposition of disease.

View Article and Find Full Text PDF

Background: Writer's cramp is a task-specific focal hand dystonia, which is diagnosed clinically. Quantification of defect in WC is done using clinical scales, while digitized platforms are lacking.

Objective: To design and test a platform that can differentiate and quantify the abnormal kinematics of writing using a software interface and to validate it in adult-onset isolated writer's cramp (WC).

View Article and Find Full Text PDF
Article Synopsis
  • India has a significant burden of cervical cancer, but low participation in screening and vaccination among women is a major challenge.
  • A study of 380 college students in Andhra Pradesh showed that only 54.7% were aware of cervical cancer, with over 71% having poor knowledge and 98.4% not practicing regular preventive measures.
  • The research highlights the urgent need for awareness programs and improved education on cervical health through social media to increase participation in screenings and vaccinations.
View Article and Find Full Text PDF

In India, the incidence of mucormycosis reached high levels during 2021-2022, coinciding with the COVID-19 pandemic. In response to this, we established a multicentric ambispective cohort of patients hospitalised with mucormycosis across India. In this paper, we report their baseline profile, clinical characteristics and outcomes at discharge.

View Article and Find Full Text PDF
Article Synopsis
  • Root and tuber crops (RTCs) like cassava, potatoes, sweet potatoes, and yams serve as staple foods for many people and have potential in industrial and bioenergy applications, but they remain underutilized due to challenges in improvement programs.
  • Advances in whole-genome sequencing have provided valuable data for crops like cassava and potato, enabling better genetic improvements and applications through new strategies such as gene editing.
  • The review highlights progress in using CRISPR/Cas9 technology to enhance RTCs, discusses strategies for genetic transformations, identifies research gaps, and addresses challenges in implementing these advanced methods.
View Article and Find Full Text PDF

This paper presents the results of two proficiency testing (PT) rounds conducted by the Export Inspection Agency (EIA) Chennai laboratory in 2021 for food testing laboratories in India. The PT program was designed in accordance with ISO/TS 22117, a standard for proficiency testing in food microbiology, and targeted and as the organisms of focus. The samples were found to be stable and recoverable during the analysis, and all PT sample packages were delivered to participant laboratories in good condition.

View Article and Find Full Text PDF

: The coronavirus disease 2019 (COVID-19) pandemic was associated with an increased incidence of mucormycosis globally. However, the clinical pattern, epidemiologic features and risk factors for adverse outcomes are not well established. : We performed a retrospective analysis of the data from patients hospitalized with proven mucormycosis between April 2021 and August 2021.

View Article and Find Full Text PDF

Familial Adult Myoclonus Epilepsy (FAME), with a prevalence of < 1/35 000, is known under different acronyms. The disease is transmitted in an autosomal dominant manner and is characterized by the occurrence of cortical myoclonic tremor, overt myoclonus, and rare bilateral tonic-clonic seizures. FAME is considered neurodegenerative, although it is relatively slow in progression.

View Article and Find Full Text PDF

Background: Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), classically presenting as a triad of early-onset cerebellar ataxia, lower extremity spasticity and peripheral neuropathy, is caused by mutations in SACS gene which encodes the protein sacsin.

Objective: To provide new insight into the occurrence of SACS mutations in South India.

Methods: Patients with three cardinal features of ARSACS-peripheral neuropathy, cerebellar ataxia, and pyramidal tract signs were included.

View Article and Find Full Text PDF

Most of the thyroid surgeries are accompanied by drain placement. The possibility of hematoma or seroma formation postoperatively is of concern to surgeons, as, thyroid is a highly vascular structure and a minor hemorrhage might also turn out to be life threatening, despite actual incidence of it being only 0.3-1%.

View Article and Find Full Text PDF

Background: Autism Spectrum Disorder (ASD) is a pervasive developmental disorder, which affects various multiple areas of a child's development. The objective of this study was to systematically review the available literature and appraise the effect of floortime in engaging autism disorder among children.

Materials And Methods: A systematic review was performed using PubMed, PsycINFO, Science Direct, Scopus, Google Scholar, and Medline.

View Article and Find Full Text PDF

A novel fluorogenic sensor N-benzo[b]thiophen-2-yl-methylene-4,5-dimethyl-benzene-1,2-diamine (BTMPD) was synthesized and characterized by using spectroscopic methods including UV-visible, FT-IR, H NMR, C NMR, and mass spectrometry. The designed fluorescent probe, owing to its remarkable properties, behaves as an efficient turn-on sensor for the sensing of amino acid Serine (Ser). Also, the strength of the probe enhances upon the addition of Ser via charge transfer, and the renowned properties of the fluorophore were duly found.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiontrj282d4ehbkn9v22lu1k3so8soonqrc): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once