Role of Oxidative Stress and DNA Damage on Preterm Birth Outcome.

Preterm birth (PTB) poses a significant global health challenge and focused research is vital for improving maternal and neonatal health outcomes. The purpose of this study was to determine the effect of oxidative stress (OS) and DNA damage on PTB. There were two groups: (a) cases consisting of mothers with PTB (<37 weeks of gestation, = 100) and (b) controls consisting of mothers with term birth (>37 weeks of gestation, = 100).

The Effect of FSHR (G2039A) Polymorphism on Müllerian Duct Development and Hormonal Profile of Women with Primary Amenorrhea.

Background: The function of follicle-stimulating hormone (FSH) is mediated by binding to its G-protein coupled receptor (GPCR) which is expressed on granulosa cells of the ovary. The purpose of the current study was to examine the impact of FSHR G2039A polymorphism (rs6166; SerAsn) on clinical and radiology profiles of women with primary amenorrhea (PA) in Gujarat, India.

Methods: A total of 90 women (45 controls and 45 cases) were recruited for the study after obtaining informed consent.

Clinical profile and cytogenetic correlations in females with primary amenorrhea.

Objective: This study was conducted to investigate chromosomal abnormalities and their correlations with clinical and radiological findings in females with primary amenorrhea (PA).

Methods: Detailed forms were recorded for 470 females, including the construction of three-generation pedigrees. Peripheral venous blood was drawn, with informed consent, for cytogenetic analysis.

Impact of atmospheric variables on incidence of acute coronary syndrome amongst Gujarati Asian Indians - IOAPIC study.

Objectives: The study evaluated the effects of climatic conditions and its variables on incidence of ACS in Gujarati Asian Indians.

Methods: In this multicentric, retrospective, observational case control study of a total of 3256 patients, the Electronic Medical Records (EMS) of all 740 patients who were hospitalised for ACS at the 2 tertiary care centres of Ahmedabad over 3 years between January 2017 to December 2019 were compared with demographically matched 2516 non- ACS, CAD controls were compared for the impact of climatic parameters viz. temperature, barometric pressure, humidity as reported by monthly averages by the state meteorological department for monthly incidence of ACS.

Genotoxic risk in occupational exposure to petrol and its amelioration by vitamin C and vitamin E.

Petrol contains mixture of mutagens and carcinogens which have potential health risk after prolonged occupational exposure. We have compared genotoxicity and its amelioration in blood samples from 70 petrol pump attendants, working in congested area of the Ahmedabad city, India and similar number ( = 70) of Control samples from office workers dwelling in less polluted areas of the city. The cytokinesis-block micronucleus assay showed highly significant frequencies of micronucleus in Exposed than in the Controls.

Women rag pickers at a dump in Ahmedabad: Genotoxicity and oxidative stress.

Municipal solid waste (MSW) generated in Ahmedabad, India, and the surrounding area is dumped at the Pirana site; rag pickers collect materials for re-sale. We have compared genotoxicity and oxidative stress in samples from women rag pickers working at this site, with women involved only in door-to-door waste picking (in residential areas near the university campus) as "controls". The buccal Cytokinesis-Block Micronucleus (CBMN) assay showed significantly higher frequencies of Micronucleus (MN), Nucleoplasmic Bridges (NPB), and Nuclear Buds (NB) in the rag pickers than in the "controls".

Cytotoxic and genotoxic effects of (Lam.) Pers. fresh leaf juice in the cultured human blood lymphocytes.

This is the first investigation on the cytotoxicological and genotoxicological effects of (Lam.) Pers. fresh leaf juice, for establishing a safe and effective quantity for use.

Genotoxic Effects of Exposure to Gasoline Fumes on Petrol Pump Workers.

Background: Petrol pump workers are occupationally exposed to gasoline and its fumes consisting of several mutagenic chemicals.

Objective: To evaluate the genotoxic effects of exposure to gasoline fumes on petrol pump workers.

Methods: The study groups included 70 petrol pump workers (exposed group) and 70 healthy age-matched individuals with no known exposure (comparison group).

Ameliorative effects of curcumin against lead induced toxicity in human peripheral blood lymphocytes culture.

Lead, a heavy metal and multifaceted toxicant, is well studied for its distribution and toxicity in ecosystem, yet there is no consensus on its amelioration by any synthetic or phytochemical compounds. Curcumin, a known antioxidant and dietary element, is a well-known herb, for its therapeutic uses and having a wide spectrum of its beneficial properties against several adverse effects. Hence, the current study was taken into consideration to evaluate the ameliorative effects of curcumin (3.