Publications by authors named "Ditiro Setlhare"
Objectives: We sought to determine vaccine antibody titres and the prevalence of hepatitis B surface antigen (HBsAg) in both HIV-positive and HIV-negative infants born to HIV-positive mothers in Botswana.
Design: This was a retrospective cross-sectional study using 449 archived dried blood spot samples from both HIV-positive and HIV-negative infants collected between 2016 and 2018.
Methods: We screened dried blood spot samples for HBsAg and determined hepatitis B surface antibody titres.
Slow CD4 T-Cell Recovery in Human Immunodeficiency Virus/Hepatitis B Virus-Coinfected Patients Initiating Truvada-Based Combination Antiretroviral Therapy in Botswana.
Motswedi Anderson Simani Gaseitsiwe Sikhulile Moyo Kerapetse P Thami Terence Mohammed Ditiro Setlhare
Open Forum Infect Dis
September 2016
Article Synopsis
- The study examines the effects of Truvada-based antiretroviral therapy on patients in Botswana who are coinfected with HIV and hepatitis B virus (HBV), comparing them to patients with only HIV.
- Out of 300 participants, 9.3% had active HBV infection, and those coinfected showed a decreased gain in CD4 T-cells and lower rates of HBV suppression after treatment compared to those without HBV.
- The results suggest that screening for HBV before starting HIV treatment can improve outcomes, highlighting the need for tailored treatment strategies for coinfected patients.