Publications by authors named "Disha Singhania"
The use of bone scaffolds to replace injured or diseased bone has many advantages over the currently used autologous and allogeneic options in clinical practice. This systematic review evaluates the current evidence for non-cellular scaffolds containing bioactive glass on osteogenesis and angiogenesis in animal bone defect models. Studies that reported results of osteogenesis via micro-CT and results of angiogenesis via Microfil perfusion or immunohistochemistry were included in the review.
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- Mesenchymal stem cells (MSCs) can help repair corneal injuries, which often lead to vision problems, and this study explored various methods of delivering MSCs to promote healing.
- The research found that delivering MSCs via subconjunctival or intravenous routes was more effective than topical or intraperitoneal methods in reducing corneal opacity and inflammation in mice with corneal injuries.
- The results indicate that subconjunctival and IV delivery methods enhance MSC presence in ocular tissues and significantly improve corneal tissue repair and integrity after injury.
The aim of this PRISMA review was to assess whether the CMI and Actifit scaffolds, when used in clinical practice, improve clinical outcomes and demonstrate the ideal biological and biomechanical properties of scaffolds: being chondroprotective, porous, resorbable, able to mature and promote regeneration of tissue. This was done by only including studies that assessed clinical outcome and used a scale to assess both integrity of the scaffold and its effects on articular cartilage via MRI. A search was performed on PubMed, EMBASE, Scopus and clinicaltrials.
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