Publications by authors named "Disha Keshwani"
Article Synopsis
- ACE2 is the main receptor for SARS-CoV-2, and this study investigates the role of specific miRNAs (miR-10b-5p, miR-124-3p, miR-200b-3p, miR-26b-5p, miR-302c-5p) in predicting COVID-19 patient outcomes and their impact on the cardiovascular system.
- The researchers measured miRNA expression in 79 hospitalized COVID-19 patients and 32 healthy volunteers at three different time points, finding that lower levels of miR-200b-3p could indicate longer hospital stays and higher mortality risk.
- The study found distinct expression patterns of miRNAs in COVID-19
Background: In patients with type 2 diabetes mellitus (T2DM) an association between severe hypoglycaemic episodes and the risk of cardiovascular (CV) morbidity and mortality has been previously established.
Methods: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR-129-2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. Selected miRNAs were validated by qRT-PCR in 14 patients with T2DM on metformin monotherapy, without established CV disease and antiplatelet therapy during a stepwise hypoglycaemic clamp experiment and a follow-up 7 days after the clamp event.