Synopsis of recent research by authors named "Disha Awasthy"
- Disha Awasthy's research primarily focuses on the discovery and optimization of novel antimycobacterial and antimalarial agents through whole cell screenings and structure-activity relationships, highlighting the efficacy of compounds against Mycobacterium tuberculosis and Plasmodium falciparum.
- Key findings include the validation of dried blood spots for whole genome sequencing, potential breakthroughs in identifying new drug targets like topoisomerase I in Mycobacterium tuberculosis, and the discovery of fast-acting antimalarial compounds from the triaminopyrimidine series.
- Awasthy has also developed methodologies to tackle technical challenges in assays, such as optimizing compound preparation to improve cytotoxicity testing in mammalian cells, thereby advancing both drug discovery and analytical techniques in microbiological research.
