Publications by authors named "Disen Yuan"
Chronic hepatitis E mostly occurs in organ transplant recipients and can lead to rapid liver fibrosis and cirrhosis. Previous studies found that the development of chronic hepatitis E virus (HEV) infection is linked to the type of immunosuppressant used. Animal models are crucial for the study of pathogenesis of chronic hepatitis E.
View Article and Find Full Text PDFAn Immunocompetent Mongolian Gerbil Model for Hepatitis E Virus Genotype 1 Infection.
Gastroenterology
September 2024
Article Synopsis
- Hepatitis E virus (HEV-1) causes millions of infections and deaths annually, and researchers are exploring whether Mongolian gerbils can serve as animal models for studying HEV-1.
- By adapting a clinical strain of HEV-1 through serial passaging in gerbils, the study successfully induced acute infections that were characterized by virus shedding and liver damage.
- This gerbil model will provide valuable insights into HEV immunopathogenesis and help evaluate potential vaccines and antiviral treatments for hepatitis E.