Publications by authors named "Dirk-Henning Menz"
Purpose: The complications with cytotoxic perfluorooctane (PFO) batches reported in 2015 were attributed to reactive underfluorinated impurities whose chemical identity and behavior still need to be clarified.
Material And Methods: We analyzed original packaged samples of Alaocta batches involved in several reported cases of retinal toxicity. (A) The impurity profile was determined.
How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?
Invest Ophthalmol Vis Sci
October 2018
Purpose: Reactive and underfluorinated impurities are acknowledged as a source of cytotoxicity of perfluorocarbon liquids (PFCLs) used as blood substitutes. To determine whether this is also a relevant factor in retinal toxicity, we analyzed eight PFO batches associated with adverse ocular events.
Methods: (A) The amount of reactive and underflurinated impurities was analyzed by fluoride-selective potentiometry and expressed as H-value.
An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses.
Graefes Arch Clin Exp Ophthalmol
June 2008
Purpose: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients.
Materials And Methods: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial.
Background: To investigate the reasons for difficulties removing silicone oil from the vitreous cavity due to putative adherence to the retina.
Methods: Gas chromatography-coupled mass spectroscopy of the headspace (GC/MS/HS) and gel permeation chromatography (GPC) were used to detect volatile compounds in silicone oil samples explanted from patients, qualitatively as well as quantitatively. Surface and interfacial tensions of the explanted samples were measured using the pendent-drop technique.
Introduction: Dynasilan is a fluoroalkylsilan that is able to interact with surface active centres on intraocular lenses (IOL), offering a new way for surface modification of different IOL materials. The purpose of this in vitro study was to investigate the influence of this new surface modification on the adherence of two typical endophthalmitis causing bacteria (Staphylococcus epidermidis, Propionibacterium acnes).
Materials And Methods: In a pilot experiment, the effect of Dynasilan coating on the adherence of S.
Purpose: To investigate the influence of other substances used intraoperatively in vitreoretinal surgery on the emulsification of silicone oil in patients' eyes.
Methods: Gas chromatography coupled mass spectroscopy of the headspace (GC/MS/HS) was used to detect volatile compounds in silicone oil samples explanted from patients qualitatively as well as quantitatively. Surface and interfacial tensions of the explanted samples were measured using the pendent drop technique.
Purpose: To investigate possible sources for the induction of silicone oil emulsification in patients' eyes.
Methods: The contaminants on a ready-to-use standard set of vitreoretinal instruments cleaned and sterilized in an eye clinic were determined. The determination of detergents was carried out according to a standardized procedure, which uses ultrapurified water to rinse the equipment in question, followed by a measurement of the conductivity.
Purpose: To investigate the solubility of perfluorocarbon liquids (PFCL) in silicone oil.
Methods: Forty-eight samples of silicone oil (1,300 mPas, n = 22; 5,000 mPas, n = 26) were analyzed for dissolved fluorocarbon molecules after surgical removal from patients who had initially undergone vitreoretinal surgery with (n = 41) and as control without (n = 7) the use of perfluorodecalin in headspace gas chromatography. In vitro, the solubility of three different PFCL-perfluorooctane (PFO), perfluorodecalin (PFD), and fluoromethylcyclohexane (FMCH)-in silicone oil of various viscosities was determined.