Circadian Rhythmicity of Vital Signs at Intensive Care Unit Discharge and Outcome of Traumatic Brain Injury.

Background: Physiological functions with circadian rhythmicity are often disrupted during illness.

Objective: To assess the utility of circadian rhythmicity of vital signs in predicting outcome of traumatic brain injury (TBI).

Methods: A retrospective single-center cohort study of adult intensive care unit (ICU) patients with largely isolated TBI to explore the relationship between the circadian rhythmicity of vital signs during the last 24 hours before ICU discharge and clinical markers of TBI severity and score on the Glasgow Outcome Scale 6 months after injury (GOS-6).