Publications by authors named "Dirk P T van Lier"
Background: The CytoSorb hemoadsorption device has been demonstrated to be capable of clearing inflammatory cytokines, but has not yet been shown to attenuate plasma cytokine concentrations. We investigated the effects of CytoSorb hemoperfusion on plasma levels of various cytokines using the repeated human experimental endotoxemia model, a highly standardized and reproducible human in vivo model of systemic inflammation and immunological tolerance induced by administration of bacterial lipopolysaccharide (LPS).
Methods: Twenty-four healthy male volunteers (age 18-35) were intravenously challenged with LPS (a bolus of 1 ng/kg followed by continuous infusion of 0.
Article Synopsis
- Dipeptidyl peptidase 3 (DPP3) is an enzyme that can show how healthy a person's organs are, especially in patients with severe illness like septic shock.
- In a study with 585 patients, higher levels of DPP3 when they first arrived at the hospital linked to a higher risk of death and organ problems after 28 days.
- If patients had high DPP3 levels but then saw their levels decrease after one day, they tended to do better, while those with still high levels had worse outcomes.
Article Synopsis
- Immune reconstitution inflammatory syndrome (IRIS) is a condition that happens when someone's immune system starts to recover, but it causes serious inflammation and tissue damage, making them feel worse.
- This usually includes symptoms like fever and might show new infections that weren’t noticed before.
- IRIS often occurs in people with HIV when their treatment helps their immune system, but it's also seen in cancer patients recovering from low white blood cells after treatments like chemotherapy.
What is the central question of this study? We explored whether heart failure (HF) patients demonstrate different exercise-induced brachial artery shear rate patterns compared with control subjects. What is the main finding and its importance? Moderate-intensity cycle exercise in HF patients is associated with an attenuated increase in brachial artery anterograde and mean shear rate and skin temperature. Differences between HF patients and control subjects cannot be explained fully by differences in workload.
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