Calcium induces tobramycin resistance in Pseudomonas aeruginosa by regulating RND efflux pumps.

Pseudomonas aeruginosa is an opportunistic multidrug resistant pathogen causing severe chronic infections. Our previous studies showed that elevated calcium (Ca) enhances production of several virulence factors and plant infectivity of the pathogen. Here we show that Ca increases resistance of P.

Calcium homeostasis in Pseudomonas aeruginosa requires multiple transporters and modulates swarming motility.

Pseudomonas aeruginosa is an opportunistic human pathogen causing severe acute and chronic infections. Earlier we have shown that calcium (Ca(2+)) induces P. aeruginosa biofilm formation and production of virulence factors.