Nrf2 Activation Protects Mouse Beta Cells from Glucolipotoxicity by Restoring Mitochondrial Function and Physiological Redox Balance.

Influencing the redox balance of pancreatic beta cells could be a promising strategy for the treatment of diabetes. Nuclear factor erythroid 2p45-related factor 2 (Nrf2) is present in beta cells and regulates numerous genes involved in antioxidant defense. As reactive oxygen species (ROS) are important for beta cell signaling but induce oxidative stress when present in excess, this study elucidates the influence of Nrf2-activating compounds on different kinds of ROS and correlates changes in redox balance to effects on mitochondrial function, insulin release, and cell viability.

Synthesis and characterization of anthracene derivative for organic field-effect transistor fabrication.

Here we report on the synthesis and characterization of anthracene derivative for solution processable organic field-effect transistors. The transistor devices with bottom-contact geometry provided a maximum field-effect mobility of 3.74 x 10(-4) cm2 V(-1) s(-1) as well as current on/off ratio of 5.

Thiadiazoloquinoxaline-acetylene containing polymers as semiconductors in ambipolar field effect transistors.

Two conjugated copolymers, PPTQT and PTTQT, were developed based on thiadiazoloquinoxalines connected via ethynylene π-spacer to thiophene units. PPTQT showed maximum hole and electron mobility of 0.028 and 0.

Asymmetric pyrene derivatives for organic field-effect transistors.

For the synthesis of an ortho-dithienylpyrene, a K-region bromination of pyrene was developed which enabled the first reported, non-statistical asymmetric functionalization of pyrene at the 4, 5, 9 and 10 positions. Crystal structures, optical and electronic properties and FET characteristics have been investigated.

Benzo[1,2-b:4,5-b']bis[b]benzothiophene as solution processible organic semiconductor for field-effect transistors.

Coplanar benzo[1,2-b:4,5-b']bis[b]benzothiophenes (, ) for the application in organic field-effect transistors were synthesized by a simple two-step procedure involving triflic acid induced ring-closure reaction; such solution processed devices show a hole mobility of up to 0.01 cm(2) V(-1) s(-1).