Publications by authors named "Diravya M Seelan"
Article Synopsis
- Diabetes mellitus (DM) affects immune responses, potentially increasing the risk for developing active tuberculosis (TB) in individuals with hyperglycemia.
- A study examined the immune function of macrophages in DM patients with and without TB, as well as in non-diabetic TB patients and controls, revealing that those with PTB+DM showed a significant reduction in phagocytic capacity.
- Key immune receptors (PRRs) were altered in expression among PTB+DM patients, leading to higher reactive oxygen species (ROS) but lower nitric oxide (NO) levels, which were linked to more severe disease outcomes.
Early identification and treatment of active tuberculosis disease among high risk household contacts could limit new transmission and better clinical outcome, thus decreasing TB burden. Host iron homeostasis is an important yet underevaluated factor in pathophysiology of tuberculosis (TB). One such protein is hepcidin which internalizes ferroportin (membrane iron transporter), thus inhibiting iron export from macrophages which is utilised by bacteria leading to disease severity.
View Article and Find Full Text PDF