Improving effect of physical exercise on heart failure: Reducing oxidative stress-induced inflammation by restoring Ca homeostasis.

Heart failure (HF) is associated with the occurrence of mitochondrial dysfunction. ATP produced by mitochondria through the tricarboxylic acid cycle is the main source of energy for the heart. Excessive release of Ca from myocardial sarcoplasmic reticulum (SR) in HF leads to excessive Ca entering mitochondria, which leads to mitochondrial dysfunction and REDOX imbalance.

Enhanced cerebral perfusion during brief exposures to cyclic intermittent hypoxemia.

Cerebral vasodilation and increased cerebral oxygen extraction help maintain cerebral oxygen uptake in the face of hypoxemia. This study examined cerebrovascular responses to intermittent hypoxemia in eight healthy men breathing 10% O for 5 cycles, each 6 min, interspersed with 4 min of room air breathing. Hypoxia exposures raised heart rate ( P < 0.

Aerobic Exercise Training Improves Orthostatic Tolerance in Aging Humans.

Purpose: This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT).

Methods: Eight healthy sedentary volunteers (67.0 ± 1.