Publications by authors named "Diquan Shuai"
Background: Allergic bronchopulmonary aspergillosis (ABPA) constantly develops in asthmatics, which has not been fully investigated.
Objectives: This study aimed to investigate serum differentially expressed proteins (DEPs) between ABPA and asthma using the new approach isobaric tags by relative and absolute quantitation (iTRAQ).
Methods: Each 16 serum samples from ABPA or asthmatic subjects were pooled and screened using iTRAQ.
Article Synopsis
- - The study explored the role of specific miRNA-mRNA interactions in the development of chronic obstructive pulmonary disease (COPD), a condition characterized by persistent airflow limitation.
- - Researchers analyzed data from the Gene Expression Omnibus using R software and identified 13 co-expressed modules, focusing on the turquoise module linked to COPD, which included 12 differentially expressed miRNAs.
- - Key findings showed that hsa-miR-664a-3p was upregulated in COPD patients and negatively impacted its target gene, leading to a correlation with lung function measures like FEV1/FVC%, indicating a potential pathway influenced by cigarette smoke.