Synthesis of R-GABA Derivatives via Pd(II) Catalyzed Enantioselective C(sp)-H Arylation and Virtual Validation with GABA Receptor for Potential leads.

GABA (γ-amino butyric acid) analogues like baclofen, tolibut, phenibut, etc., are well-known GABA inhibitors and pharmaceutically important drugs. However, there is a huge demand for more chiral GABA aryl analogues with promising pharmacological actions.