Publications by authors named "Dipan Saha"
Background: The isometric handgrip (IHG) test is commonly used to detect sympathetic autonomic dysfunction. Tamsulosin, approved for the management of symptomatic benign prostatic hyperplasia (BPH), acts as an antagonist for α1-adrenergic receptors (α1-AR), whereas prazosin, an α receptor blocker, being less selective than tamsulosin, is used as an antihypertensive agent clinically. Our objective was to investigate if there is a distinction in blood pressure (BP) increase during IHG exercise between individuals with essential hypertension taking tamsulosin compared to those taking prazosin.
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- Gestational hypertension poses risks for both mothers and babies, potentially leading to conditions like preeclampsia; this study investigates sympathetic nervous system function in affected women.
- The study included 52 women with pregnancy-induced hypertension and 52 without, assessing their blood pressure responses to exercise to determine differences in autonomic function.
- Results indicated significantly higher blood pressure responses in the hypertensive group, suggesting that the increased sympathetic activity is linked to a higher risk of developing preeclampsia or eclampsia, highlighting a potential area for new treatments.