Sphaeranthus indicus flower derived constituents exhibits synergistic effect against acetylcholinesterase and possess potential antiamnestic activity.

Objective: The present investigation was aimed at discovery of novel acetylcholinesterase (AChE) inhibitors.

Methods: In vitro AchE inhibitory activity of various extracts of Sphaeranthus indicus flower heads was carried out. The petroleum ether fraction of S.