Publications by authors named "Diogo Canhoto"
Article Synopsis
- The SHARP study aimed to gather real-world evidence on severe asthma treatment by linking data from 10 different national registries across Europe, focusing on patients treated with mepolizumab.
- The analysis, which included 912 patients, found that mepolizumab significantly reduced the frequency of asthma exacerbations and the use of maintenance oral glucocorticoids before and during the COVID-19 pandemic.
- The study highlighted considerable variation in patient characteristics and treatment practices between the different registries, emphasizing the diverse nature of severe asthma management in Europe.
During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative burden associated with AD. However, the mechanisms behind the effects of chronic hyperglycemia in the context of AD are not fully understood.
View Article and Find Full Text PDF