Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients.

Objective: To characterize the reversibility of natalizumab-mediated changes in pharmacokinetics/pharmacodynamics in patients with multiple sclerosis (MS) following therapy interruption.

Methods: Pharmacokinetic/pharmacodynamic data were collected in the Safety and Efficacy of Natalizumab in the Treatment of Multiple Sclerosis (AFFIRM) (every 12 weeks for 116 weeks) and Randomized Treatment Interruption of Natalizumab (RESTORE) (every 4 weeks for 28 weeks) studies. Serum natalizumab and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured using immunoassays.

Cardiac rehabilitation for a skydiver after aortic valve replacement for pure aortic regurgitation and resection of the ascending aorta complicated by active infective endocarditis and heart block requiring a pacemaker.

A professional skydiver underwent aortic valve and ascending aorta replacement complicated by infective endocarditis with root abscess and pacemaker implantation. He then enrolled in the Baylor Heart and Vascular Hospital cardiac rehabilitation (CR) program as part of its specificity of testing and exercise training facility. He performed specific skydiving cardiovascular and muscular strength tests at the beginning and the end of the CR program.

Exposure-disease response analysis of natalizumab in subjects with multiple sclerosis.

Natalizumab, a human immunoglobulin monoclonal antibody that targets αβ/αβ integrin, is an effective therapy approved for the treatment of multiple sclerosis (MS). The objective of this analysis was to develop a population exposure-response model utilizing gadolinium-enhancing (Gd) lesion count data from four clinical studies and annualized relapse rate (ARR) data from three clinical studies. The natalizumab exposures were derived for the individuals using a population pharmacokinetic model.

Mortality rate in patients with nosocomial Acinetobacter meningitis from a Brazilian hospital.

Background: The mortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high.

Objective: The aim of this study was to evaluate the factors that have influence over the outcomes in ANM patients.

Methods: A retrospective analysis of 22 cases of ANM was conducted in a hospital with high incidence of multidrug resistance.