Publications by authors named "Diogenes Coelho Junior"
Microb Pathog
October 2022
Article Synopsis
- ApoE is essential for transporting lipoproteins in the liver, and its deficiency leads to atherosclerosis in mice, especially as they age.
- Infection with Trypanosoma cruzi, a protozoan that induces strong inflammation, exacerbates atherosclerosis in ApoE-knockout mice, with increased inflammation markers and cell migration to the heart observed.
- The study indicates that ApoE has a protective effect against atherosclerosis during acute T. cruzi infection, particularly with the Colombian strain, suggesting that targeted interventions could help reduce cardiovascular risks in affected individuals.
