Publications by authors named "Dinoi G"
Background: Despite discouragement from many scientific societies, routine preoperative testing remains a common practice. Minor gynaecological surgery, being widely performed in everyday practice, represents an opportunity for implementing cost-reduction policies by avoiding unnecessary diagnostic assessments.
Objectives: To assess whether performing routine preoperative blood tests affects postoperative complications and cost-effectiveness in patients undergoing minor gynaecological surgery.
Article Synopsis
- * The main health risks associated with TSC include brain tumors, sudden unexpected death due to epilepsy, and respiratory issues, which lead to significant morbidity and mortality.
- * While there are therapies available for TSC, there's a need for more research into its neurological effects and for developing new treatment options, including the repurposing of existing drugs and targeting new mechanisms.
Article Synopsis
- The study focuses on two siblings who inherited two new variants (N935Y and H1393Q) in the Nav1.1 sodium channel, leading to a drug-responsive neurological condition while their parents remain asymptomatic.
- Most variants in this channel are usually inherited heterozygously, but in this case, both siblings express a biallelic (two copies) inheritance pattern.
- Functional analyses of sodium currents show that these variants reduce channel activity by about 20%, potentially contributing to their illness, but also suggest that other factors could play a role in the disease's development.
Purpose: To assess prognostic significance of residual tumor at repeat transurethral resection (reTUR) in contemporary non-muscle-invasive bladder cancer (NMIBC) patients.
Methods: Patients were identified retrospectively from eight referral centers in France, Italy and Spain. The cohort included consecutive patients with high or very-high risk NMIBC who underwent reTUR and subsequent adjuvant BCG therapy.
Objective: Understanding ovarian involvement incidence and risk factors in women with endometrial cancer may inform the decision of ovary preservation.
Methods: Our retrospective study included all consecutive fully surgically staged patients with endometrial cancer who underwent primary surgery between January 2005 and November 2021, assessing the incidence of ovarian metastasis, its role as a prognostic factor for recurrence and death, and evaluated predictors of adnexal involvement.
Results: Women with International Federation of Gynecology and Obstetrics (FIGO) 2009 IIIA endometrial cancer comprised 2.
Article Synopsis
- Aging leads to sarcopenia, characterized by loss of muscle strength and increased fatigue, partially due to reduced essential amino acid intake affecting muscle health.
- A study shows that branched-chain amino acid (BCAA) supplements can improve muscle weakness and atrophy in aged mice, particularly when combined with L-alanine.
- Findings indicate that calcium homeostasis is disrupted in aged muscles, but BCAAs, especially the BCAAs+L-alanine combination, can restore some of these calcium-related dysfunctions, highlighting their potential in addressing age-related muscle decline.
Article Synopsis
- Oral anticoagulant therapy for atrial fibrillation includes traditional vitamin K antagonists like warfarin and newer direct-acting oral anticoagulants (DOACs) such as dabigatran and rivaroxaban, with DOACs being preferred due to lower bleeding risks.
- Anticoagulant switching from warfarin to DOACs is a common practice, but understanding the implications of this switch, especially for patients with both atrial fibrillation and heart failure, remains crucial.
- A machine learning analysis was conducted to examine the effects of switching from warfarin to DOACs in heart failure patients with atrial fibrillation, highlighting the positive impacts of DOACs beyond just preventing blood clots
Objectives: The goal of this study was to evaluate the depth of myometrial invasion as a predictor of distant recurrence in patients with node-negative stage IB endometrioid endometrial cancer.
Methods: A retrospective multicenter study, including surgically staged endometrial cancer patients at Mayo Clinic, Rochester (MN, USA) between January 1999 and December 2017, and Fondazione Policlinico Universitario A. Gemelli (Rome, Italy) between March 2002 and March 2017, was conducted.
Objectives: To assess predictors of extensive lymph node dissemination and non-vaginal recurrence in patients with endometrial cancer with positive sentinel lymph nodes (SLNs).
Methods: Patients with endometrial cancer who underwent primary surgery with SLN mapping and had at least one positive node between October 2013 and May 2019 were included. Positive SLNs were reviewed, and cases were classified according to the location of the metastasis (extracapsular vs intracapsular), and the size of the largest SLN metastasis (isolated tumor cells, micrometastasis, macrometastasis).
Background: Nearly 65% of patients with endometrial cancer who undergo primary hysterectomy have concurrent obesity. Retrospective data show advantages in using robotic surgery in these patients compared with conventional laparoscopy, namely lower conversion rate, increased rate of same-day discharge, and reduced blood loss. Nevertheless, to date no prospective randomized controlled trials have compared laparoscopic surgery versus robotic-assisted surgery in morbidly obese patients.
View Article and Find Full Text PDFObjective: Endometrial cancer stage is a strong prognostic factor; however, the current stage classification does not incorporate transtubal spread as determined by intraluminal tumor cells (ILTCs). We examined relationships between ILTCs and survival outcomes according to histological subtype and stage and examined whether identification of ILTCs improves prognostic accuracy of endometrial cancer staging.
Methods: We conducted a retrospective cohort study of women diagnosed with endometrial cancer at five academic hospitals between 2007 and 2012.
Article Synopsis
- Brugada syndrome (BrS) is a complex inherited cardiac condition recognized since 1992, posing challenges in diagnosis, risk assessment for arrhythmias, and management.
- Approximately 20% of individuals with BrS have genetic variants, but a growing understanding of its polygenic nature suggests the use of polygenic risk scores for better individual risk prediction.
- Current research aims to uncover biomarkers for diagnosing and managing BrS, advocating for a comprehensive model that considers clinical, genetic, and environmental factors to improve patient outcomes.
Objective: To identify predictors of quality of life (QoL) among patients who undergo surgical staging with sentinel lymph node (SLN) biopsy or lymphadenectomy for endometrial cancer.
Methods: Patients who underwent minimally invasive surgery for primary endometrial cancer at the Mayo Clinic from October 2013 to June 2016 were mailed a 30-item QoL in Cancer survey (QLQ-C30) and a validated 13-item lower extremity lymphedema screening questionnaire. Patients who answered <50% of the items or had a pre-operative history of lymphedema were excluded.
Article Synopsis
- SGLT2 inhibitors (gliflozins) are gaining attention as a treatment for heart failure with reduced left ventricular ejection fraction (HFrEF), but their full effects on heart function remain unclear.
- A study involving 78 diabetic patients used machine learning to analyze how well these medications worked, revealing specific echocardiographic parameters that could predict the treatment response.
- The analysis indicated that while gliflozins helped improve heart remodeling and function, their effectiveness decreased with more severe heart damage, highlighting the importance of monitoring healthy heart metrics for better treatment outcomes.
Objective: To evaluate the diagnostic performance of the one-step nucleic acid amplification (OSNA) method for the detection of sentinel lymph node (SLN) metastases in women with apparent early-stage endometrial cancer compared with standard ultrastaging.
Methods: Prospective, multicentric, interventional study. Patients with apparent early-stage endometrial cancer who underwent primary surgical staging with SLN mapping were included.
Purpose: The aim of this study is to evaluate the impact of the oestrogen receptor (ER) profile on oncologic outcomes in the new endometrial cancer (EC) risk classification.
Methods: Immunohistochemistry (IHC) analyses were performed in a retrospectively reviewed large series of ECs to assess the presence/absence of oestrogen receptors (ER0\1+ or ER2+\3+) and other molecular factors (i.e.
Article Synopsis
- Sarcalumenin (SAR) is a calcium buffer protein primarily found in skeletal muscles and the heart, crucial for regulating calcium uptake and release during muscle contractions.
- SAR has a high capacity but low affinity for binding calcium and works alongside other calcium buffer proteins, influencing various physiological processes like SERCA stabilization and muscle fatigue resistance.
- Despite its similarities to the well-known calsequestrin, research on SAR is limited, and this review aims to highlight its importance in muscle function and potential involvement in muscle wasting disorders.
Article Synopsis
- Non-dystrophic myotonias consist of different conditions, including myotonia congenita and other forms caused by gene mutations in CLCN1 and SCN4A.
- A study analyzed five affected family members and discovered two novel gene mutations, p.K1302R in SCN4A and p.H838P in CLCN1, which were shown to co-segregate with the disorder.
- Experiments revealed that while the mutations led to mild functional changes in ion channels, these changes could explain the mixed myotonic symptoms and suggested that medications like mexiletine and lamotrigine could be beneficial for those carrying the K1302R mutation.
Objective: To compare outcomes between minimally invasive surgery and open surgery in patients with high-risk endometrial cancer.
Data Sources: A cohort study of all patients who underwent surgery for high-risk endometrial cancer between 1999 and 2016 at Mayo Clinic (Rochester, Minnesota) and a literature search of MEDLINE, EMBASE, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials, and Scopus of all published studies until December 2020.
Background: complete uterine septum, double cervix and vaginal septum is a rare complex Müllerian anomaly affecting patients' quality of life in terms of fertility and pelvic pain. The aim of our review is to gather the studies concerning the diagnosis and treatment this complex malformation and to describe the related fertility outcomes.
Methods: this study was conducted in 2022, according to the criteria of Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and the protocol was submitted to the International Prospective Register for Systematic Reviews (PROSPERO).
Background: Endometrial cancer is the most common gynaecological tumour in developed countries. The overall rate of relapse has remained unchanged in recent decades. Recurrences occur in approximately 20% of endometrioid and 50% of non-endometrioid cases.
View Article and Find Full Text PDFArticle Synopsis
- - Researchers found a new mutation in the Kv1.1 gene linked to neurological issues like epilepsy and ataxia in a young girl, and noted that treatments with standard medications were initially ineffective.
- - The study aimed to understand how this specific mutation affects the function of the Kv1.1 channel by comparing it to the normal version, revealing that the mutation causes reduced potassium current and altered function.
- - Findings suggest that mutations in the Kv1.1 channel are associated with severe epilepsy, and highlight the effectiveness of certain medications, like acetazolamide, in treating conditions related to this channel's dysfunction.
Hysteroscopic uterine evacuation of early pregnancy loss using tissue removal devices seems to be a safe and feasible procedure in selected cases. The hysteroscopic approach allows the precise localisation of the gestational sac inside the uterine cavity. The endoscopic approach allows one to perform hysteroembryoscopy before uterine evacuation and this technique appears to be more accurate than dilatation & curettage for fetal chromosome karyotyping, with lower maternal cell contamination.
View Article and Find Full Text PDFObjective: To compare disease-free survival between minimally invasive surgery and open surgery in patients with high-risk endometrial cancer.
Methods: We conducted a multicentric, propensity-matched study of patients with high-risk endometrial cancer who underwent hysterectomy, bilateral salpingo-oophorectomy, and staging between January 1999 and June 2016 at two centers. High-risk endometrial cancer included grade 3 endometrioid, serous, clear cell, undifferentiated carcinoma or carcinosarcoma with any myometrial invasion.
4K versus 3D total laparoscopic hysterectomy by resident in training: a prospective randomised trial.
Facts Views Vis Obgyn
September 2021
Background: The introduction of ultra-high-definition laparoscopic cameras (4K), by providing stronger monocular depth perception, could challenge the existing 3D technology. There are few available studies on this topic, especially in gynaecological setting.
Objectives: Prospective, single institution, randomised clinical trial (NCT04209036).