Age-dependent systemic DNA damage in early Type 2 Diabetes mellitus.

Oxidative stress, capable of eliciting damage to various biomolecules including DNA, is a recognized component of diabetes mellitus and its complications. Metabolic syndrome (MetS) is associated with the development of type 2 diabetes mellitus (T2DM), as well as other unfavorable outcomes. The aim of this study was to elucidate the role of oxidative stress in the development of T2DM, by investigating association of oxidative DNA damage with metabolic parameters in subjects with MetS and early T2DM.

Level of primary DNA damage in the early stage of metabolic syndrome.

Metabolic syndrome (MetS) is a multi-component disease, characterised by abdominal obesity, hypertension, hyperglycaemia and dyslipidaemia. Since the number of MetS patients has significantly increased over the past two decades and because MetS may lead to development of cardiovascular diseases, diabetes type-2, and cancer, it has become important to extend the knowledge on the pathogenesis of MetS and to establish its possible early biomarkers. Studies on MetS and DNA damage are few and are inconclusive.

Fatty liver index as an indicator of metabolic syndrome.

Objective: The aim of this study was to find an early indicator of metabolic syndrome (MetS).

Design And Methods: We measured several anthropometric, biochemical, haematological, and oxidative damage parameters in 128 middle-aged Caucasian men divided into two groups: patients with MetS (n=69) and healthy controls (n=59), and used Weka REPTree and SimpleCART algorithms to identify the most reliable predictor of MetS.

Results: Oxidative damage parameters did not differ between the groups, suggesting that oxidative damage is less prominent at the early stage of MetS.

Extreme hyperkalaemia caused by concomitant use of a NSAID and an ace inhibitor in an elderly patient.

Extreme hyperkalaemia is a life-threatening electrolyte disorder. It is relatively common in patients with severe renal insufficiency. This report describes a case of extreme hyperkalaemia caused by drugs in an 82-year-old female patient without severe renal insufficiency, who was successfully treated without haemodialysis.