Publications by authors named "Dinithi Mudalige"

Article Synopsis
  • This study examined how the characteristics of study partners (SPs)—including age, sex, and relationship to the participant—affect the reporting of neuropsychiatric symptoms (NPS) in individuals across different cognitive states: cognitively normal, mild cognitive impairment, and dementia.
  • The research utilized data from a large cohort, analyzing 26,748 cross-sectional and 12,794 longitudinal cases from the National Alzheimer's Coordinating Center to determine trends and associations.
  • Findings revealed that younger, female, and spousal SPs reported NPS more often, indicating that SP characteristics may play a significant role in assessing mild behavioral impairment (MBI) and predicting dementia risk, highlighting the importance of considering these factors for accurate evaluations and treatment planning
View Article and Find Full Text PDF
Article Synopsis
  • Physical inactivity during mid-life increases the risk of dementia, while mild behavioral impairment (MBI) may indicate early neurodegenerative changes.
  • The study analyzed data from CAN-PROTECT to examine how different types of physical activity (like cardiovascular exercise and physical labor) relate to MBI severity, finding a significant link.
  • Specifically, higher cardiovascular activity was associated with lower MBI severity (8.42% decrease per standard deviation increase), whereas increased physical labor led to higher MBI severity (5.64% increase), indicating the potential for cardiovascular exercise to mitigate dementia risk markers in older adults.
View Article and Find Full Text PDF

Background: Clinical guidelines recommend incorporating non-cognitive markers like mild behavioral impairment (MBI) and sleep disturbance (SD) into dementia screening to improve detection.

Objective: We investigated the longitudinal associations between MBI, SD, and incident dementia.

Methods: Participant data were from the National Alzheimer's Coordinating Center in the United States.

View Article and Find Full Text PDF