Labdane- diterpenoids and sesquiterpenes from and their nitric oxide inhibitory activity in lipopolysaccharide-stimulated RAW264.7 macrophages.

One new labdane- diterpenoid, 3,15-dihydroxylabda-8(17),12-dien-16,15-olide () named curcumatin and twelve known compounds, coronarin D (), isocoronarin D (), ()-labda-8(17),12-diene-15,16-dial (), zerumin A (), ()-labda-8(17),12-dien-15,16-dioic acid (), furanodiene (), linderazulene (), zedoarol (), zedoarondiol (), germacrone-1,10-epoxide (), germacrone-4,5-epoxide (), and zingiberenol () were isolated from the ethanol extract of the roots of Salisb. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, and comparing with the NMR data reported in the literature. Compounds , , and significantly inhibited the nitric oxide production effect in LPS-stimulated RAW 264.

Tumor genomic profiling and personalized tracking of circulating tumor DNA in Vietnamese colorectal cancer patients.

Background: Colorectal cancer (CRC) is the fifth most common cancer with rising prevalence in Vietnam. However, there is no data about the mutational landscape and actionable alterations in the Vietnamese patients. During post-operative surveillance, clinical tools are limited to stratify risk of recurrence and detect residual disease.

Genetic landscape and personalized tracking of tumor mutations in Vietnamese women with breast cancer.

Breast cancer is the leading cause of cancer death in Vietnamese women, but its mutational landscape and actionable alterations for targeted therapies remain unknown. After treatment, a sensitive biomarker to complement conventional imaging to monitor patients is also lacking. In this prospective multi-center study, 134 early-stage breast cancer patients eligible for curative-intent surgery were recruited.