The dynamics impact of phlorizin on gut microbiota and metabolites in an in vitro fermentation model.

The multiple beneficial effects, but low bioavailability of phlorizin (PHZ) have sparked discussion about its role in interaction with the gut microbiota. In this study, the effects of PHZ on the fecal microbiota animals of different origins were investigated using an in vitro fermentation model. In the fermentation system of PHZ using SD rat feces, the dynamic variations of the bacterial profile, SCFAs, and organic acids were detected using 16S rRNA gene sequencing, GC-MS, and LC-MS/MS.