FeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones.

An efficient hydrazine substitution of p-nitro-aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups also smoothly proceeded under mild conditions.

Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19.

COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, M inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors.

[Approach to the road of vigorously developing Chinese medicine by scientific location of channels and collaterals].

Through researches of channels and collaterals and clinical practice of many years, the authors understand that Chinese medicine, which considers the human body as an interrelated, mutual constraints, whole, dynamic living system, has gradually become an important part of modern medicine. Channels and collaterals are a closed loop system which is communicated and linked by energy and information in the form of electromagnetic oscillation, reflecting many characteristics similar to quantum. Channels and collaterals are not a fixed organizational structure.

[Meridian regulation is a course of communicating and implicating of the informational system with the material system].

Objective: To approach to the intrinsic mechanism of meridian regulation.

Methods: Summarize and analyze the results of the author's studies and the development of other studies about life regulating and meridian at home and abroad.

Conclusion: The regulating mechanism of meridians has two levels.

[Relationship of meridians with human material and energy systems study on theory and clinical application of meridians (IV)].

Objective: To expound the relationship between meridians and the human two information systems, material system and energy system.

Methods: Summarize and analyze the results of experimental and other studies.

Conclusion: The carrier of the meridian is human material system.

[Study on theory and clinical application of meridians (III)].

Objective: To probe into essence of meridians.

Methods: To examine meridians, acupoints, brain and relative organs by SQUID and fMRI, and to analyze the results.

Conclusion: A relative stable circular current of electromagnetic and chemical oscillation along the low electric resistance pathway was found.