IL-32 Promotes the Radiosensitivity of Esophageal Squamous Cell Carcinoma Cell through STAT3 Pathway.

Objective: This study is set out to determine the relationship between IL-32 and radiosensitivity of esophageal squamous cell carcinoma (ESCC).

Methods: Western blot was adopted for measuring IL-32 expression in Eca-109 and TE-10 cells. Eca-109 and TE-10 cells with interference or overexpression of IL-32 were treated with the presence or absence of X-ray irradiation.

PBX1 Increases the Radiosensitivity of Oesophageal Squamous Cancer by Targeting of STAT3.

The radioresistance of oesophageal squamous cell carcinoma (OSCC) is a critical factor leading to a poor prognosis among patients. The expression of PBX1 is abnormally high in a broad range of human tissues, and this gene plays a key role in tumour proliferation. This research intended to explore the radiosensitization of OSCC by silencing PBX1.

MiR-450a-5p inhibits autophagy and enhances radiosensitivity by targeting dual-specificity phosphatase 10 in esophageal squamous cell carcinoma.

Radioresistance reduces the success of therapy for patients with ESCC. Enhancing our understanding of the cardinal principles of radioresistance may improve the response of patients to irradiation. MicroRNAs perform a key role in posttranscriptional regulation, which is linked with the response of tumors to irradiation.

Long-Term Results and Predictors of Survival After Conservative Breast Surgery for Breast Cancer During Pregnancy.

BACKGROUND Breast cancer is one of the most frequently encountered malignancies in women. Although the prognosis is good for most breast cancer patients, little is known about the outcomes of breast carcinoma during pregnancy. The long-term results and predictors of survival of conservative breast surgery for breast cancer during pregnancy are especially unclear.