Publications by authors named "Dingyuan Dai"
Cisplatin is widely used in anti-tumor therapy, but the ototoxicity caused by high-dose cisplatin often limits its efficacy, and the specific mechanism of cisplatin-induced cochlear damage is still not perfect. The Wnt/β-catenin signaling pathway is closely related to aging, embryonic development, and apoptosis. Meanwhile, B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1) plays a certain role in the evolution and development of the inner ear and the occurrence and development of inner ear-related diseases.
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- * Research has advanced in understanding how cisplatin causes ototoxicity, but the specific mechanisms are still not fully understood, and the best protective agents to prevent this side effect have not yet been identified.
- * This review discusses various cell death mechanisms involved in cisplatin-induced ototoxicity and emphasizes the need for better protective strategies, which could lead to improved treatments for patients undergoing cisplatin chemotherapy.