Facile fabrication of THz metasurfaces by a spatially shaped femtosecond laser printing system.

Terahertz (THz) metasurfaces provide unprecedented abilities to realize versatile THz wavefronts manipulations. Nevertheless, these high degree of freedom, non-periodic, densely arranged subwavelength unit cells pose numerous extreme parameter requirements for the fabrication of metasurfaces, presenting significant challenges to their practical application. Herein, a spatial shaping femtosecond laser printing system, based on spatial light modulation (SLM), is proposed for the creation of THz metasurfaces.

Triple therapy boosts survival in NSCLC patients with brain metastases: a retrospective cohort study of chemotherapy, ICIs, and antiangiogenic agents.

Background: Treatment of brain metastases (BMs) in non-small cell lung cancer (NSCLC) patients, especially those with non-sensitive genetic mutations, is hindered by limited drug delivery through the blood-brain barrier (BBB). This retrospective study explores the efficacy of systemic treatments during brain metastasis to radiotherapy evaluation window in improving patient survival.

Methods: In this retrospective cohort study, we evaluated 209 NSCLC patients with non-sensitive mutations and BMs, treated between 2016 and 2023 at two tertiary medical centers (Chongqing University Cancer Hospital and Guangxi Medical University Cancer Hospital).

Piezoelectricity in wide bandgap semiconductor 2D crystal GaN nanosheets.

Gallium nitride (GaN) exhibits various potential applications in optics and optoelectronics due to its outstanding physical characteristics, including a wide direct bandgap, strong deep-ultraviolet emission, and excellent electron transport properties. However, research on the piezoelectric and related properties of GaN nanosheets are scarce, as previous small-scale GaN investigations have mainly concentrated on nanowires and nanotubes. Here, we report a strategy for growing 2D GaN nanosheets using chemical vapor deposition on Ga/W liquid-phase substrates.

Fu'cupping Physical Permeation-Enhancing Technique Enhances the Therapeutic Efficacy of Corydalis yanhusuo Gel Plaster.

, a traditional Chinese medicine, is widely used to treat various pains, and its active ingredients are alkaloids. This study aimed to develop a new type of transdermal gel plaster containing the extract of . Studies have shown that Fu'cupping physical permeation-enhancing technique can promote the penetration of alkaloids and improve the efficacy of drugs.

Characterization of the High-Quality Genome Sequence and Virulence Factors of f. sp. Race 7.

f. sp. () is a common soilborne fungal pathogen that causes Fusarium wilt (FW) disease in cotton.

Asymmetric Synthesis of the Functionalized A/E-Ring Fragment of C-Diterpenoid Alkaloids.

A new asymmetric synthesis of the A/E-ring fragment of C-diterpenoid alkaloids is described. The crucial contiguous stereogenic centers at C4, C5, and C11 were established through an asymmetric Michael addition/allylation sequence. The unique azabicyclo[3.

Above-Room-Temperature Strong Ferromagnetism in 2D MnB Nanosheet.

Two-dimensional (2D) room-temperature (RT) ferromagnetic materials have amassed considerable interest in the field of fundamental physics for applications in next-generation spintronic devices owing to their physical properties. However, realizing strong RT ferromagnetism and a high Curie temperature () in these 2D magnetic materials remains challenging. Herein, we develop a 2D MnB nanosheet for known 2D ferromagnets that demonstrates strong RT ferromagnetism and a record-high above-RT of ∼585.

Realization of Robust and Ambient-Stable Room-Temperature Ferromagnetism in Wide Bandgap Semiconductor 2D Carbon Nitride Sheets.

Due to their weak intrinsic spin-orbit coupling and a distinct bandgap of 3.06 eV, 2D carbon nitride (CN) flakes are promising materials for next-generation spintronic devices. However, achieving strong room-temperature (RT) and ambient-stable ferromagnetism (FM) remains a huge challenge.

Decreased zinc-fingers and homeoboxes family expression was associated with unfavorable outcomes and immune infiltration in lung adenocarcinoma.

Background: The zinc-fingers and homeoboxes (ZHX) family is a group of nuclear homodimeric transcriptional repressors that play an essential role in developing and progressing diverse malignancies. However, the association of ZHX family expression with prognosis and immune infiltration in lung adenocarcinoma (LUAD) is still unclear. The current study aimed to investigate the relationship between ZHX family expression and clinical outcomes and immune infiltration in LUAD patients.

Intrinsic piezoelectricity of 2D violet phosphorene.

Violet phosphorene (VP) has an extensive range of potential uses in piezoelectric gadgets due to its excellent electron transport capabilities. Nevertheless, VP materials are devoid of the piezoelectric effect because of the absence of ionic polarity. In this study, the piezoelectric capacity of the VP nano-sheet was investigated.

Rational Design of Biological Crystals with Enhanced Physical Properties by Hydrogen Bonding Interactions.

Hydrogen bonds are non-covalent interactions and essential for assembling supermolecules into ordered structures in biological systems, endowing crystals with fascinating physical properties, and inspiring the construction of eco-friendly electromechanical devices. However, the interplay between hydrogen bonding and the physical properties is not fully understood at the molecular level. Herein, we demonstrate that the physical property of biological crystals with double-layer structures could be enhanced by rationally controlling hydrogen bonding interactions between amino and carboxyl groups.

Nomogram prediction for the risk of venous thromboembolism in patients with lung cancer.

Objective: The aim of this study was to establish a nomogram graph model to accurately predict the venous thromboembolism (VTE) risk probability in the general population with lung cancer.

Methods: Based on data from patients with lung cancer in Chongqing University Cancer Hospital of China, the independent risk factors of VTE were identified by the logistic univariable and multivariable analysis and were integrated to construct a nomogram, which was validated internally. The predictive effectiveness of the nomogram was evaluated by the receiver operating characteristic curve (ROC) and calibration curve.

Fast-speed, Highly Sensitive, Flexible Humidity Sensors Based on a Printable Composite of Carbon Nanotubes and Hydrophilic Polymers.

Carbon nanotubes (CNTs) are a promising material for humidity sensors and wearable electronics due to their solution capability, good flexibility, and high conductivity. However, the performance of CNT-based humidity sensors is limited by their low sensitivity and slow response. Herein CNTs and hydrophilic polymers were mixed to form a composite.

Immobilization of Zn(Ⅱ) and Cu(Ⅱ) in basic magnesium-sulfate-cementitious material system: Properties and mechanism.

To solve the environmental problems caused by heavy metal pollution, a new cementitious material (basic magnesium sulfate cement, BMSC) was developed for the solidification of Cu/Zn. First, the effects of different amounts of Cu/Zn on the properties (compressive strength, setting time, pH, and leaching toxicity) of the BMSC were investigated. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) were used to investigate the effects of different amounts of Cu/Zn on the phase and microstructure of BMSC.

Piezo-Activated Atomic-Thin Molybdenum Disulfide/MXene Nanoenzyme for Integrated and Efficient Tumor Therapy via Ultrasound-Triggered Schottky Electric Field.

Monolayer molybdenum disulfide (MoS ) nanoenzymes exhibit a piezoelectric polarization, which generates reactive oxygen species to inactivate tumors under ultrasonic strain. However, its therapeutic efficiency is far away from satisfactory, due to stackable MoS , quenching of piezo-generated charges, and monotherapy. Herein, chitosan-exfoliated monolayer MoS (Ch-MS) is composited with atomic-thin MXene, Ti C (TC), to self-assemble a multimodal nanoplatform, Ti C -Chitosan-MoS (TC@Ch-MS), for tumor inactivation.

Pseudo-siamese network combined with dosimetric and clinical factors, radiomics features, CT images and 3D dose distribution for the prediction of radiation pneumonitis: A feasibility study.

Purpose: Radiation pneumonitis (RP)(grade ≥ 2) can have a considerable impact on patient quality-of life. In previous studies, the traditional method commonly used radiomics and clinical factors for RP prediction. This study aims to develop and evaluate a novel pseudo-siamese network (PSN) to assist radiologists predict RP before radiotherapy based on combination of dosimetric and clinical factors, radiomics features, CT (computed tomography) images, and dose distribution (hybrid model).

Constructing Heterogeneous Photocatalysts Based on Carbon Nitride Nanosheets and Graphene Quantum Dots for Highly Efficient Photocatalytic Hydrogen Generation.

Although graphitic carbon nitride nanosheets (CNs) with atomic thickness are considered as promising materials for hydrogen production, the wide band gap (3.06 eV) and rapid recombination of the photogenerated electron-hole pairs impede their applications. To address the above challenges, we synergized atomically thin CNs and graphene quantum dots (GQDs), which were fabricated as 2D/0D Van der Waals heterojunctions, for H generation in this study.

Preparation of magnesium potassium phosphate cement using by-product MgO from Qarhan Salt Lake for low-carbon and sustainable cement production.

Herein, to reduce CO emissions and energy consumption and to promote the recycling of waste resources, two types of boron-containing MgO by-products, which were obtained by lithium extraction from Qarhan Salt Lake, China, were used as substitutes for dead-burned MgO to prepare magnesium phosphate potassium cement (MKPC) as a rapid repair material. First, the phase composition and particle-size distribution of the MgO by-product were investigated. The effects of different MgO sources, molar ratio of MgO to KHPO (M/P), and curing age on the setting time and mechanical properties of MKPC were then studied.

Identification of Angiogenesis-Related Prognostic Biomarkers Associated With Immune Cell Infiltration in Breast Cancer.

This study aimed to explore the prognostic value of angiogenesis-related genes (ARGs) and their association with immune cell infiltration (ICI) in breast cancer (BC). Transcriptome data of BC were obtained from the TCGA and GEO databases. Differentially expressed ARGs were identified by the limma package.

Polyphenols in Ilex latifolia Thunb. inhibit human lung cancer cell line A549 by regulation of the PI3K-Akt signaling pathway.

Background: The leaves of the plant Ilex latifolia Thunb. can be made into Kuding tea, which is a drink rich in polyphenols. This study aimed to observe the effect of Ilex latifolia Thunb.

Construction of a prognostic risk model of colorectal adenocarcinoma through integrated analysis of RNA-binding proteins.

Background: RNA binding proteins (RBPs) play an important role in a variety of cancers. However, their mechanisms in cancer progression are still limited especially in colorectal adenocarcinoma (COAD). Integrated analysis of RBPs will provide a better understanding of disease genesis and new insights into COAD treatment.

Characteristics of stereotactic radiotherapy clinical trials registered on ClinicalTrials.gov.

Background: We aim to analyze the characteristics of stereotactic radiotherapy trials registered on ClinicalTrials.gov, and to compare completed and stopped early trials to identify predictors of trial failure.

Methods: All interventional stereotactic radiotherapy trials registered on ClinicalTrials.