['s academic view of "synergistic effect of moxibustion combined with medication" and its application in tumor rehabilitation].

In clinical practice of moxibustion, Professor has found that many symptoms are related to deficiency, cold and dampness accumulation or deficiency, and the obstruction of and blood. The therapeutic effects on these symptoms are not satisfactory with either herbal medication or western drugs. But, the effects can be obviously improved by replenishing with heat-sensitive moxibustion and medication in combination.

The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.

Background: High-frequency repeated transcranial magnetic stimulation (rTMS) stimulating the primary motor cortex (M1) is an alternative, adjunctive therapy for improving the motor symptoms of Parkinson's disease (PD). However, whether the high frequency of rTMS positively correlates to the improvement of motor symptoms of PD is still undecided. By controlling for other parameters, a disease animal model may be useful to compare the neuroprotective effects of different high frequencies of rTMS.

's clinical experience of heat-sensitive moxibustion for in treatment of insomnia of deficiency.

The paper introduces 's experience and ideas of heat-sensitive moxibustion for (warming-up and nourishing the spirit) in treatment of insomnia of deficiency. This type of insomnia is caused by insufficiency of the body and malnutrition of the spirit. The treatment focuses on .

[Advantages and application prospects of heat-sensitive moxibustion robot].

Moxibustion therapy is a unique health resource in China, which is advantageous by its irreplaceable effectiveness in treatment, disease prevention and healthcare. But, moxibustion therapy used in primary care institutions in China is far from the due role of this therapy played in medical practice. The authors believe that the heat-sensitive moxibustion (HSM) robot should be developed by integrating the manipulation of moxibustion therapy with modern artifical intelligence technology so that moxibustion therapy can be operated precisely and easily, deqi of moxibustion be effectively stimulated and the cost of its manual manipulation be reduced.

Efficacy of acupuncture therapy for post-stroke fatigue: a systematic review and Meta-analysis.

Objective: To assess the effectiveness and safety of acupuncture for post-stroke fatigue (PSF).

Methods: Eight online databases were searched to collect relevant trials of acupuncture for PSF published before April 2021. Meta-analysis was performed by using RevMan 5.

[Effect of moxibustion with on Aβ-receptor mediated transport and enzymatic degradation in hippocampus in rats with Alzheimer's disease].

Objective: To observe the clinical effect of moxibustion with on Alzheimer's disease (AD) rats, and evaluate its effect on β-amyloid (Aβ) transport and enzymatic degradation proteins, to explore its molecular mechanism for improving cognitive function.

Methods: Sixty SPF-grade male SD rats were randomly divided into a blank group (8 rats), a sham-operation group (8 rats) and a model establishment group (44 rats). The rats in the model establishment group were injected with Aβ- at bilateral ventricles to establish AD model.

[Discussion of novel mode of acupuncture and moxibustion based on identifying the acupoint sensitization].

On the base of the paradigms of clinical studies on modern moxibustion by identifying the acupoint sensitization, the records of ancient literature in successive dynasties were collected on "identifying the sensitization" of acupoints in acupuncture. In association with acupoint detection of acupuncture recorded in current textbooks, a novel concept, "exerting acupuncture by identifying the acupoint sensitization" is proposed. Acupoint sensitization is the common initial link of effect achieved by both acupuncture and moxibustion.

Blocking N-Methyl-D-aspartic Acid (NMDA) Receptor Inhibits Heat-Sensitization Response of Moxibustion in Stroke Rats.

Our previous studies demonstrated that effects of moxibustion heavily relied on heat-sensitization response, a specific sensation induced by moxibustion in the ill body. On the sensation, long-term potentiation (LTP) of prelimbic cortex was attributed to heat-sensitization responses. The N-methyl-D-aspartic acid (NMDA) receptor plays a key role in LTP induction; however, little is known about the role of NMDA receptor in heat-sensitization response.

The effectiveness of Du moxibustion for chronic obstructive pulmonary disease: A protocol for systematic review and meta-analysis of randomized clinical trials.

Background: As a common respiratory disease, Chronic Obstructive Pulmonary Disease (COPD) develops progressively. Du moxibustion can effectively treat COPD, and no adverse reactions have been reported. This research mainly evaluated the efficacy and safety of Du moxibustion in the treatment of COPD.

Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis.

Objective: The aim of this systematic review was to summarize and evaluate the existing evidence on the effectiveness and safety of acupuncture in relieving chronic pain-related depression (CPRD).

Methods: We searched seven online databases to identify eligible randomized controlled trials (RCTs) of acupuncture for CPRD published before September 2020. We included studies that used acupuncture as the intervention group, with or without a control group, and the control group was treated with conventional drugs.

42 cases of coronavirus disease 2019 of the ordinary type with the adjuvant treatment of heat-sensitive moxibustion 42.

Objective: To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019 (COVID-19) of the ordinary type.

Methods: A total of 42 patients with COVID-19 of the ordinary type were adopted. Shénquè ( CV8) and Tiānshū ( ST25) were selected.

[Clinical observation of heat-sensitive moxibustion treatment for coronavirus disease 2019].

Objective: To observe clinical effect of heat-sensitive moxibustion on coronavirus disease 2019 (COVID-19) and to discusses the effective moxibustion treatment program.

Methods: A total of 42 patients with COVID-19 (general type) were treated with heat-sensitive moxibustion at the acupoint area of Shenque (CV 8) and Tianshu (ST 25). The treatment was conducted under the standards of heat-sensitive moxibustion manipulation, which were "locating acupoint by feeling, moxibustion by differentiate sensation, dosage varies individually, ending after sufficient dosage".

[Application of professor 's academic thought " is often insufficient, but is often surplus" in heat-sensitive moxibustion for tumor rehabilitation].

Professor has explored the causes of the characteristics of TCM syndromes in modern disease spectrum and pointed out that the TCM syndromes are generally characterized by " is often insufficient, but is often surplus". Based on the clinical experience and the understanding of TCM classics and ancient literature on tumor, professor has proposed that TCM syndromes of patients with advanced tumor are also generally characterized by " is often insufficient, but is often surplus". The heat-sensitive moxibustion has the functions of warming and nourishing eliminating dampness, warming meridians and dispersing cold, activating blood circulation and clearing collaterals, therefore tumor patients with deficiency syndrome (-deficiency, deficiency), cold syndrome, dampness syndrome, phlegm syndrome and blood-stasis syndrome belonging to the indications of heat-sensitive moxibustion.

[On the in moxibustion].

The original connotation of in () was explored to provide the reference for the clinical application of moxibustion. The relevant items of the original definition of in were traced aligning with the achievements in the clinical researches on the heat-sensitive phenomena and its rule, and thus, the characteristics of in moxibustion and its inducing approaches were analyzed. A new viewpoint of the connotation of in was put forward.

Long-Term Potentiation of Prelimbic Cortex Ascribed to Heat-Sensitization Responses of Moxibustion.

Heat-sensitization responses occurred in certain patients while exposed to suspended moxibustion. The response often indicated that the efficacy of moxibustion to those with it tended to triumph over those without. However, its mechanism remains to be explained.

[Development and initial evaluation of sensation scale of heat-sensitive moxibustion].

Based on heat-sensitive moxibustion (HSM) theory, a widely applicable scale was developed to reflect the (arrival of ) sensation of HSM. By documentary method and interviewing method, the items of describing sensation of HSM were collected to establish the pool of candidate items. With expert questionnaire, patient questionnaire and core expert discussion, the items were screened and quantified by method of subjective evaluation to develop the initial draft of the scale.

[Clinical Observation of Heat-sensitive Moxibustion Combined with Kegel Exercise Therapy for Female Stress Urinary Incontinence].

Objective: To compare the clinical effects of heat-sensitive moxibustion combined with kegel exercise therapy and simple kegel exercise therapy on female stress urinary incontinence.

Methods: Forty-five female patients with stress urinary incontinence were randomly divided into a treatment group (=23) and a control group (=22). Kegel exercise therapy was applied in the two groups.

[Professor 's views on moxibustion sensation].

The sensation of heat-sensitive moxibustion (HSM) refers to the heat feeling at distal and deep part of the body when a patient is treated with moxibustion under unhealthy status, which may even transmits to the disease sites, instead of heat feeling at local and superficial part of the body. Professor has systema-tically studied the HSM sensation and its clinical laws through clinical practice; he points out different HSM sensations contain different physiological and pathological information of the human body, which could reflex the severity of diseases, so the collection of HSM information should be emphasized; the type and intensity of HSM sensation could guide the clinical acupoint selection and precise localization. The appearance and disappearance of HSM sensation could be applied to establish individual amount of moxibustion, and disappearance of HSM sensation is an appropriate signal for sufficient moxibustion time, which break through the concept of fixed time at each acupoint, and provide measurement standard to make full use of moxibustion.

[Characteristics and clinical application of the arrival of qi in suspended moxibustion].

The characteristics and clinical application of the arrival of qi in suspended moxibustion was discussed in this paper. Through literature research and clinical practice, three aspects, including characteristics of arrival of qi in suspended moxibustion, the clinical basis regarding arrival of qi in suspended moxibustion improving therapeutic effects and how to acquire arrival of qi in suspended moxibustion, were discussed to clarify the essential role of arrival of qi in suspended moxibustion as well as its importance to the development of moxibustion medicine. The suspended moxibustion at acupoints could produce arrival of qi similar to acupuncture, which was characterized as non-local or non-superficial heat sensation such as penetrating heat, expanding heat, transmitting heat, even non-hot sensation such as aching, numbing, distending, painful, heavy, cold sensation in the applied region.

[Different Warm Sensations May Induce Different Therapeutic Effects in Primary Dysmenorrhea Patients Undergoing Moxibustion Treatment Based on Propensity Score: A Prospective Cohort Study].

Objective: To compare the effectiveness difference between the "heat-sensitive" sensation and conventional warm sensation of moxibustion stimulation of Guanyuan (GV 4) in primary dysmenorrhea (PD) patients.

Methods: Cohort study design was used in the present study. A total of 189 PD patients were divided into heat-sensitive group (n = 148) and conventional warm sensation group (n = 41) according to the patients' subjective feeling to moxibustion stimulation and the sequence of treatment.

[Efficacy evaluation of heat-sensitive moxibustion for chemotherapy symptoms of large intestine cancer].

Objective: To analyze and evaluate the clinical efficacy of heat-sensitive moxibustion for symptoms of large intestine cancer.

Methods: Sixty patients with large intestine cancer were randomly divided into an observation group and a control group, 30 cases in each one. FOLFOX chemotherapy regimen was used in the two groups,and heat-sensitive moxibustion was added in the observation group.

Heat-sensitive moxibustion in patients with osteoarthritis of the knee: a three-armed multicentre randomised active control trial.

Background: In China, heat-sensitive moxibustion (HSM) is used for knee osteoarthritis (KOA) to reduce pain and improve physical activity. However, there is little high-quality evidence of its effectiveness.

Objective: To evaluate the effectiveness of HSM in the treatment of KOA compared with usual care.

[The two-step location method of acupoint in Internal Canon of Medicine and its clinical application].

An accurate location of acupoint is one of the key factors for improving clinical therapeutic effect of acupuncture and moxibustion. From the theoretical basis, operation method, principle discussion and clinical application, the clinical practicability of the two-step location method of acupoint in Internal Canon of Medicine is discussed. This two-step location method is in accord with the original connotation of acupoint, and focuses on the function state of acupoint.

Effectiveness and safety of heat-sensitive moxibustion on bronchial asthma: a meta-analysis of randomized control trials.

Objective: To systematically evaluate the effectiveness and safety of heat-sensitive moxibustion (HSM) on asthma.

Methods: Large databases in China and overseas were searched by electronic and manual means to collect information on randomized controlled trials (RCTs). Two evaluators independently extracted data and evaluated the quality of RCTs according to Cochrane Review Handbook v5.

A 3-Arm, Randomized, Controlled Trial of Heat-Sensitive Moxibustion Therapy to Determine Superior Effect among Patients with Lumbar Disc Herniation.

Systematic reviews of moxibustion for LDH have identified ponderable evidence, especially for heat-sensitive moxibustion (HSM). Therefore, we designed and carried out the large sample trial to evaluate it. 456 patients were recruited from 4 centers in China and were randomly divided into three groups by the ratio of 1 : 1 : 1 to HSM (152) group, conventional moxibustion (152) group, and conventional drug plus acupuncture (152) group.