Publications by authors named "Dingkai Lou"
ACS Cent Sci
November 2024
Article Synopsis
- Chemoenzymatic dynamic kinetic resolution (DKR) combines a metal racemization catalyst and an enzyme to effectively convert racemic compounds into enantiopure products, with compatibility between the two catalysts as a significant challenge.
- The study introduces a reliable ligand that enhances the coordination between the metal and the ligand, enabling better performance in the DKR process.
- An efficient DKR method was developed using a copper catalyst and lipase LPL-311-Celite, successfully producing high yields of chiral BINOLs and other functionalized chiral biaryls, with a proposed mechanism involving a radical-anion intermediate facilitating the reaction.
