Publications by authors named "Dingjie Liu"
Background: The potential of preoperative CT in the assessment of myeloid immune response and its application in predicting prognosis and immune-checkpoint therapy outcomes in hepatocellular carcinoma (HCC) has not been explored.
Methods: A total of 165 patients with pathological slides and multi-phase CT images were included to develop a radiomics signature for predicting the imaging-based myeloid response score (iMRS). Overall survival (OS) and recurrence-free survival (RFS) were assessed according to the iMRS risk group and validated in a surgical resection cohort ( = 98).
Objective: To investigate the influencing factors of dysphagia in Alzheimer's disease (AD) patients.
Methods: The study evaluated the demographic characteristics, nutritional status, social functioning, and swallowing dysfunction of 109 hospitalized AD patients.
Results: The sample include 65.
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor involved in innate immunity, but its role in adaptive immunity, specifically in the context of CD8 T-cell antitumour immunity, remains unclear. Here, we demonstrate that RIG-I is upregulated in tumour-infiltrating CD8 T cells, where it functions as an intracellular checkpoint to negatively regulate CD8 T-cell function and limit antitumour immunity. Mechanistically, the upregulation of RIG-I in CD8 T cells is induced by activated T cells, and directly inhibits the AKT/glycolysis signalling pathway.
View Article and Find Full Text PDFTransarterial embolization, the first-line treatment for hepatocellular carcinoma, does not always lead to promising outcomes in all patients. A better understanding of how the immune lymphocyte changes after transarterial embolization might be the key to improve the efficacy of transarterial embolization. However, there are few studies evaluating immune lymphocytes in transarterial embolization patients.
View Article and Find Full Text PDFArticle Synopsis
- Cyclin D1 acts as a sensor for cell growth signals, linking external factors to cell cycle control and is crucial for processes like cell differentiation and DNA repair; its malfunction can lead to cancer.
- It is often found in high levels in papillary thyroid carcinoma (PTC), yet the ways it drives this cancer remain unclear.
- The review focuses on understanding how cyclin D1 is overexpressed in PTC, its role in tumor formation, interactions with other cellular factors, and recent advancements in developing targeted therapies.