Publications by authors named "Dingjiang Qin"
LINC01579-204 involved in the development of Hirschsprung's disease maybe by regulating the expression of miR-203a-3p and NEFL.
Clin Res Hepatol Gastroenterol
December 2023
Article Synopsis
- Hirschsprung's disease (HD) is a rare congenital condition affecting children and involves malformations in the digestive tract, with limited understanding of long non-coding RNAs (lncRNAs) in this disease.
- A study analyzed lncRNA profiles in normal versus stenosed intestinal tissue from HD patients, discovering 90 differentially expressed lncRNAs, notably seeing LINC01579-204 and NEFL decrease while miR-203a-3p increased in stenosed tissues.
- The research suggests that LINC01579-204, miR-203a-3p, and NEFL play significant roles in HD progression and may help predict patient outcomes, offering new insights into the disease's molecular mechanisms.*
Background: Hirschsprung disease (HSCR) is a congenital intestinal malformation. Previous HSCR animal model needs invasive operation on adult animal. The aim of this study is to establish an early-onset animal model which is consistent with the clinical manifestation of HSCR patients.
View Article and Find Full Text PDFSusceptibility of Polymorphism to Hirschsprung Disease in Southern Chinese Children.
Clin Exp Gastroenterol
May 2023
Introduction: Hirschsprung's disease (HSCR) is a developmental defect of the enteric nervous system (ENS), which is caused by abnormal development of enteric neural crest cells. Its occurrence is caused by genetic factors and environmental factors. It has been reported that single nucleotide polymorphisms (SNPs) of proprotein convertase subtilisin/kexin type 2 () gene are associated with HSCR.
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