Developing Topics.

Background: The gut microbiota plays a certain role in Alzheimer's disease, and various types of enteritis can also cause disturbances in the gut microbiota. Recently, researchers have substantially highlighted the effect of some enteritis on Alzheimer's disease incidence and development. In this study, we elucidated the correlation between mucosal proctocolitis and Alzheimer's disease and possible mechanism.

Developing Topics.

Background: Hyperlipoprotein cholesterolemia increases the risk of Alzheimer's disease(AD). LDL is mainly responsible for the risk. However, lipoprotein have different densities, different particle sizes, and different compositions.

Developing Topics.

Background: Alzheimer's disease (AD) is associated with abnormal glucose tolerance. However, the contributing factors are unknown. We aim to find markers of Alzheimer's disease in association with abnormal glucose tolerance.

Developing Topics.

Background: Some studies have reported that neurodegenerative diseases can have different effects on the structure and function of peripheral organs, including organ volumes, and we wondered whether there is a genetic causal relationship between the two and whether changes in the volumes of parenchymal organs can affect the risk of developing neurodegenerative diseases.

Method: Our SNP data were obtained from several different databases, including UKB and IEU OpenGWAS, and we analyzed them using bidirectional Mendelian randomization followed by comprehensive robustness analysis.

Result: For traditional genetic threshold: belly subcutaneous fat tissue volume can increase the risk of Alzheimer's disease.

A 48-year-old man with fever, nauseous, vomiting, and dizzy: A CARE case report.

Rationale: Listeria monocytogenes (LM) is an important foodborne bacterium, and LM meningoencephalitis is rare in clinical practice, with poor prognosis in severe patients. It is prone to misdiagnosis in clinical practice. We first reported a case of severe LM meningoencephalitis with muscle lesions and evaluated the comprehensive condition.

Intracranial hypertension as the primary symptom of malignant melanoma: A case report.

Background: The etiological diagnosis of intracranial hypertension is quite complicated but important in clinical practice. Some common causes are craniocerebral injury, intracranial space-occupying lesion, subarachnoid hemorrhage, and hydrocephalus. When a patient presents with intracranial hypertension, the common causes are to be considered first so that other causes would be dismissed.

Environmental risk factors provoke new thinking for prevention and treatment of dementia with Lewy bodies.

In recent years, environmental factors have received attention in the pathogenesis of neurodegenerative diseases. Other than genetic factors, the identification of environmental factors and modifiable risk factors may create opportunities to delay the onset or slow the progression of Lewy body disease. Researchers have made significant progress in understanding environmental and modifiable risk factors over the past 30 years.